anti-Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) Antibodies

RUNX1T1 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. Additionally we are shipping RUNX1T1 Proteins (6) and RUNX1T1 Kits (4) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
RUNX1T1 862 Q06455
RUNX1T1 12395 Q61909
RUNX1T1 362489  
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Top anti-RUNX1T1 Antibodies at antibodies-online.com

Showing 10 out of 47 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB WB Suggested Anti-RUNX1T1 Antibody Titration: 0.2-1 ug/mlELISA Titer: 1:312500Positive Control: 293T cell lysate 100 μL Log in to see 2 to 3 Days
$319.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RUNX1T1 Antibody Titration:  1.25ug/ml  Positive Control:  HepG2 cell lysate There is BioGPS gene expression data showing that RUNX1T1 is expressed in HepG2 Host:  Rabbit  Target Name:  WT1  Sample Type:  721_B  Antibody Dilution:  1.0ug/ml  RUNX1T1 is supported by BioGPS gene expression data to be expressed in 721_B 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated ChIP, ELISA 50 μL Log in to see 2 to 3 Days
$245.00
Details
Bat Rabbit Un-conjugated WB 100 μL Log in to see 11 to 14 Days
$493.17
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Bat Rabbit Un-conjugated WB 100 μL Log in to see 11 to 14 Days
$551.83
Details
Dog Rabbit Un-conjugated WB 100 μL Log in to see 11 to 14 Days
$581.17
Details
Human Mouse Un-conjugated IF, WB Anti-RUNX1T1 mouse monoclonal antibody (ABIN2455775) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY RUNX1T1 (RC222426). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RUNX1T1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-RUNX1T1. 0.1 mL Log in to see 2 to 3 Days
$482.90
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (38.21 KDa) . 50 μL Log in to see 11 to 12 Days
$238.67
Details
Human Rabbit Un-conjugated IHC, WB Western blot analysis of extracts of HepG2 and SH-SY5Y cells, using RUNX1T1 antibody. Western blot analysis of extracts of various cell lines, using RUNX1T1 antibody (ABIN4905073) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 1s. 100 μL Log in to see 11 to 13 Days
$366.77
Details

Top referenced anti-RUNX1T1 Antibodies

  1. Human Polyclonal RUNX1T1 Primary Antibody for ELISA, WB - ABIN560189 : Abdelhaleem: RNA helicases: regulators of differentiation. in Clinical biochemistry 2005 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal RUNX1T1 Primary Antibody for IHC - ABIN965546 : Liu, Shen, Huynh, Klisovic, Rush, Ford, Yu, Becknell, Li, Liu, Vukosavljevic, Whitman, Chang, Byrd, Perrotti, Plass, Marcucci: Interplay of RUNX1/MTG8 and DNA methyltransferase 1 in acute myeloid leukemia. in Cancer research 2005 (PubMed)
    Show all 10 Pubmed References

More Antibodies against RUNX1T1 Interaction Partners

Zebrafish Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) interaction partners

  1. Results found that runx1(W84X/W84X) mutation led to the reduction and disordering of B cells, as well as the failure of V(D)J rearrangements in B cells but not T cells, resulting in antibody-inadequate-mediated immunodeficiency. By contrast, T cell development was not affected. Furthermore, an evolutionarily conserved function of runx1 was demonstrated in maturation and differentiation of B cells in adult zebrafish.

Human Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) interaction partners

  1. Minimal residual disease (MRD) monitoring and mutational landscape in AML with RUNX1-RUNX1T1.

  2. Study reports differential regulation of gene expression by RUNX1-RUNX1T1 oncoprotein and MAPK1 as determined by genome-wide expression analysis responsible for the phenotypic features of acute myeloid leukaemia with karyotypic discernible translocation (t)(8;21)(q22;q22).

  3. identified most of these factors as RUNX1-RUNX1T1 targets, with Ras Homolog Family Member (RHOB) overexpression being the core of this network

  4. lncRNA RUNX1-IT1 was down regulated both in colorectal cancer tissues and cell lines; besides, lncRNA RUNX1-IT1 could serve as a potential diagnostic biomarker and play a tumour-suppressive role owing to its good diagnostic efficacy and inhibition of colorectal cancer cell proliferation and migration

  5. As most transcriptional repressor proteins do not comprise tetramerization domains, our results provide a possible explanation as to the reason that RUNX1 is recurrently found translocated to ETO family members

  6. PKM2 as a novel target of RUNX1-ETO and is specifically downregulated in RUNX1-ETO positive AML patients, indicating that PKM2 level might have a diagnostic potential in RUNX1-ETO associated AML.

  7. The specific association of ZBTB7A mutations with t(8;21) rearranged acute myeloid leukaemia points towards leukemogenic cooperativity between mutant ZBTB7A and the RUNX1/RUNX1T1 fusion protein has been reported.

  8. Data indicate miR-29b-1 as a regulator of the AML1-ETO protein (RUNX1-RUNX1T1), and that miR-29b-1 expression in t(8;21)-carrying leukemic cell lines partially rescues the leukemic phenotype.

  9. Altogether, these results revealed an unexpected and important epigenetic mini-circuit of AML1-ETO/THAP10/miR-383 in t(8;21) acute myeloid leukaemia, in which epigenetic suppression of THAP10 predicts a poor clinical outcome and represents a novel therapeutic target.

  10. RUNX1-RUNX1T1 transcript levels were measured in bone marrow samples collected from 208 patients at scheduled time points after transplantation. Over 90% of the 175 patients who were in continuous complete remission had a >/=3-log reduction in RUNX1-RUNX1T1 transcript levels from the time of diagnosis at each time point after transplantation and a >/=4-log reduction at >/=12 months.

  11. The data suggest that the tumor suppressor activity of both RUNX1t1 and TFF1 are mechanistically connected to CEBPB and that cross-regulation between CEBPB-RUNX1t1-TFF1 plays an important role in gastric carcinogenesis.

  12. RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells

  13. Leukaemogenesis by AML1-ETO requires enhanced C/D box snoRNA/RNP formation.

  14. Study demonstrated that TRiC's contribution to the activity of the DNA-binding domain (AML1-175) of AML1-ETO is consistent with its contribution to the activity of full-length AML1-ETO and is mediated through its direct association with the DNA-binding domain

  15. the AML1-ETO fusion protein increases the expression of SIRT1, possibly by binding to the promoter region of SIRT1 to activate its transcription in t(8;21) AML.

  16. A feedback circuitry involving miR-9-1 and RUNX1-RUNX1T1.

  17. The role of RUNX1T1 in t(8;21) acute myeloid leukemia and miRNA expression regulation

  18. Our data revealed a novel role for RUNX1T1 as a tumor-suppressor gene in colorectal cancer through modulation of multiple cellular pathways affecting the cell cycle, DNA damage, DNA replication, estrogen signaling, and drug resistance

  19. Exon splicing patterns in the human RUNX1-RUNX1T1 fusion gene present in acute myeloid leukemia patients have been decoded.

  20. Data suggest that biosynthesis and folding of leukemogenic fusion oncoprotein AML1-ETO/RUNX1-RUNX1T1 is facilitated by interaction with the chaperonin TRiC/CCT1/TCP1 and HSP70 (heat shock protein 70).

Mouse (Murine) Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) interaction partners

  1. Results suggest that AML1/ETO expression determines a more mobile and less adherent phenotype in preleukemic cells, therefore altering the interaction with the hematopoietic niche, potentially leading to the migration across the bone marrow barrier and to disease progression

  2. The data suggest that the tumor suppressor activity of both RUNX1t1 and TFF1 are mechanistically connected to CEBPB and that cross-regulation between CEBPB-RUNX1t1-TFF1 plays an important role in gastric carcinogenesis.

  3. RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells

  4. Leukaemogenesis by AML1-ETO requires enhanced C/D box snoRNA/RNP formation.

  5. Data show that RUNX1-ETO;c-Kit(T417IDelta418-419) coexpression promoted exclusively acute myeloid leukemia (AML) in a fraction (51%) of reconstituted mice.

  6. Self-renewal induced by AML1/ETO in primary murine progenitors was inhibited when Aes was decreased or absent.

  7. AML1-ETO synergizes with an ICSBP deficiency to induce myeloblastic transformation in the bone marrow, reminiscent of acute myelogenous leukemia

  8. molecular role for ETO in normal physiology as an inhibitor of C/EBPbeta and a novel regulator of early adipogenesis

  9. the loss of the molecular events of AML1-ETO C-terminal NCoR/SMRT-interacting domain transforms AML1-ETO into a potent leukemogenic protein

  10. p15(Ink4b) loss must be accompanied by additional oncogenic changes for RUNX1-ETO-associated AML to develop

  11. AML1 DNA-binding domain and the ETO NHR2-dimerization domain, but not the ETO NHR1 domain, are critical for the induction of acute myeloid leukemia by AML1-ETO9a

  12. the eTAFH-E protein interaction appears to contribute relatively little to the activity of AML1-ETO

RUNX1T1 Antigen Profile

Protein Summary

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with RUNX1T1

  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (runx1t1) antibody
  • RUNX1 translocation partner 1 L homeolog (runx1t1.L) antibody
  • RUNX1 translocation partner 1 (RUNX1T1) antibody
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (Runx1t1) antibody
  • RUNX1 translocation partner 1 (Runx1t1) antibody
  • AML1T1 antibody
  • Cbfa2t1 antibody
  • Cbfa2t1h antibody
  • CDR antibody
  • ETO antibody
  • MTG8 antibody
  • si:ch211-232j17.1 antibody
  • wu:fi14b07 antibody
  • zgc:154044 antibody
  • ZMYND2 antibody

Protein level used designations for RUNX1T1

protein CBFA2T1 , MTG8 , MTG8/ETOb , expressed during postmitotic spinal neurons, most likely in motorneurons , acute myelogenous leukemia 1 translocation 1, cyclin-D related , core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related , eight twenty one protein , myeloid translocation gene on 8q22 , zinc finger MYND domain-containing protein 2 , CBFA2T1 identified gene homolog , acute myelogenous leukemia 1 translocation 1 protein , core-binding factor, runt domain, alpha subunit 2 , cyclin D-related , translocated to, 1

GENE ID SPECIES
767809 Danio rerio
733153 Xenopus laevis
395503 Gallus gallus
862 Homo sapiens
487044 Canis lupus familiaris
12395 Mus musculus
362489 Rattus norvegicus
100155449 Sus scrofa
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