anti-Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) Antibodies

RUNX1T1 encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression.

list all antibodies Gene Name GeneID UniProt
Anti-Human RUNX1T1 RUNX1T1 862 Q06455
Anti-Mouse RUNX1T1 RUNX1T1 12395 Q61909
Anti-Rat RUNX1T1 RUNX1T1 362489  
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Top anti-RUNX1T1 Antibodies at antibodies-online.com

Showing 10 out of 48 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Cow Rabbit Un-conjugated IHC, WB <b>WB Suggested Anti-RUNX1T1 Antibody Titration: </b>0.2-1 ug/ml<br><b>ELISA Titer: </b>1:312500<br><b>Positive Control: </b>293T cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB 100 μL Log in to see 2 to 3 Days
$289.00
Details
Cow Rabbit Un-conjugated WB WB Suggested Anti-RUNX1T1 Antibody Titration:  1.25ug/ml  Positive Control:  HepG2 cell lysate There is BioGPS gene expression data showing that RUNX1T1 is expressed in HepG2 Host:  Rabbit  Target Name:  WT1  Sample Type:  721_B  Antibody Dilution:  1.0ug/ml  RUNX1T1 is supported by BioGPS gene expression data to be expressed in 721_B 100 μL Log in to see 2 to 3 Days
$229.00
Details
Human Rabbit Un-conjugated ChIP, ELISA 50 μL Log in to see 2 to 3 Days
$245.00
Details
Bat Rabbit Un-conjugated WB 100 μg Log in to see 7 to 9 Days
$493.17
Details
Dog Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Bat Rabbit Un-conjugated WB 50 μg Log in to see 7 to 9 Days
$551.83
Details
Human Mouse Un-conjugated IF, WB Anti-RUNX1T1 mouse monoclonal antibody (ABIN2455775) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY RUNX1T1 (RC222426). HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RUNX1T1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-RUNX1T1. 0.1 mL Log in to see Available
$482.90
Details
Human Mouse Un-conjugated ELISA, WB Western Blot detection against Immunogen (38.21 KDa) . 50 μL Log in to see 11 to 12 Days
$305.71
Details
Human Mouse Un-conjugated WB Western Blot analysis of RUNX1T1 expression in transfected 293T cell line by RUNX1T1 monoclonal antibody (M01), clone 5A12. Lane 1: RUNX1T1 transfected lysate(67.566 KDa). Lane 2: Non-transfected lysate. Detection limit for recombinant GST tagged RUNX1T1 is approximately 0.3 ng/mL as a capture antibody. 0.1 mg Log in to see 8 to 11 Days
$450.00
Details

Top referenced anti-RUNX1T1 Antibodies

  1. Human Polyclonal RUNX1T1 Primary Antibody for ELISA, WB - ABIN560189 : Abdelhaleem: RNA helicases: regulators of differentiation. in Clinical biochemistry 2005 (PubMed)
    Show all 4 Pubmed References

More Antibodies against RUNX1T1 Interaction Partners

Human Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) interaction partners

  1. Data indicate miR (show MLXIP Antibodies)-29b-1 as a regulator of the AML1 (show RUNX1 Antibodies)-ETO protein (RUNX1 (show RUNX1 Antibodies)-RUNX1T1), and that miR (show MLXIP Antibodies)-29b-1 expression in t(8;21)-carrying leukemic cell lines partially rescues the leukemic phenotype.

  2. Altogether, these results revealed an unexpected and important epigenetic mini-circuit of AML1 (show RUNX1 Antibodies)-ETO/THAP10 (show THAP10 Antibodies)/miR (show MLXIP Antibodies)-383 in t(8;21) acute myeloid leukaemia, in which epigenetic suppression of THAP10 (show THAP10 Antibodies) predicts a poor clinical outcome and represents a novel therapeutic target.

  3. RUNX1 (show RUNX1 Antibodies)-RUNX1T1 transcript levels were measured in bone marrow samples collected from 208 patients at scheduled time points after transplantation. Over 90% of the 175 patients who were in continuous complete remission had a >/=3-log reduction in RUNX1 (show RUNX1 Antibodies)-RUNX1T1 transcript levels from the time of diagnosis at each time point after transplantation and a >/=4-log reduction at >/=12 months.

  4. The data suggest that the tumor suppressor activity of both RUNX1t1 and TFF1 (show TFF1 Antibodies) are mechanistically connected to CEBPB (show CEBPB Antibodies) and that cross-regulation between CEBPB (show CEBPB Antibodies)-RUNX1t1-TFF1 (show TFF1 Antibodies) plays an important role in gastric carcinogenesis.

  5. RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells

  6. Leukaemogenesis by AML1 (show RUNX1 Antibodies)-ETO requires enhanced C/D box snoRNA/RNP (show RNPC3 Antibodies) formation.

  7. Study demonstrated that TRiC's contribution to the activity of the DNA-binding domain (AML1 (show RUNX1 Antibodies)-175) of AML1 (show RUNX1 Antibodies)-ETO is consistent with its contribution to the activity of full-length AML1 (show RUNX1 Antibodies)-ETO and is mediated through its direct association with the DNA-binding domain

  8. the AML1 (show RUNX1 Antibodies)-ETO fusion protein increases the expression of SIRT1 (show SIRT1 Antibodies), possibly by binding to the promoter region of SIRT1 (show SIRT1 Antibodies) to activate its transcription in t(8;21) AML (show RUNX1 Antibodies).

  9. A feedback circuitry involving miR (show MLXIP Antibodies)-9-1 and RUNX1 (show RUNX1 Antibodies)-RUNX1T1.

  10. The role of RUNX1T1 in t(8;21) acute myeloid leukemia (show BCL11A Antibodies) and miRNA expression regulation

Mouse (Murine) Runt-Related Transcription Factor 1, Translocated To, 1 (Cyclin D-Related) (RUNX1T1) interaction partners

  1. Results suggest that AML1 (show RUNX1 Antibodies)/ETO expression determines a more mobile and less adherent phenotype in preleukemic cells, therefore altering the interaction with the hematopoietic niche, potentially leading to the migration across the bone marrow barrier and to disease progression

  2. The data suggest that the tumor suppressor activity of both RUNX1t1 and TFF1 (show TFF1 Antibodies) are mechanistically connected to CEBPB (show CEBPB Antibodies) and that cross-regulation between CEBPB (show CEBPB Antibodies)-RUNX1t1-TFF1 (show TFF1 Antibodies) plays an important role in gastric carcinogenesis.

  3. RUNX1T1 serves as a common angiogenic driver for vaculogenesis and functionality of endothelial lineage cells

  4. Leukaemogenesis by AML1 (show RUNX1 Antibodies)-ETO requires enhanced C/D box snoRNA/RNP (show RNPC3 Antibodies) formation.

  5. Data show that RUNX1 (show RUNX1 Antibodies)-ETO;c-Kit (show KIT Antibodies)(T417IDelta418-419) coexpression promoted exclusively acute myeloid leukemia (show BCL11A Antibodies) (AML (show RUNX1 Antibodies)) in a fraction (51%) of reconstituted mice.

  6. Self-renewal induced by AML1 (show RUNX1 Antibodies)/ETO in primary murine progenitors was inhibited when Aes (show AES Antibodies) was decreased or absent.

  7. AML1 (show RUNX1 Antibodies)-ETO synergizes with an ICSBP (show IRF8 Antibodies) deficiency to induce myeloblastic transformation in the bone marrow, reminiscent of acute myelogenous leukemia

  8. molecular role for ETO in normal physiology as an inhibitor of C/EBPbeta (show CEBPB Antibodies) and a novel regulator of early adipogenesis

  9. the loss of the molecular events of AML1 (show RUNX1 Antibodies)-ETO C-terminal NCoR (show NCOR1 Antibodies)/SMRT-interacting domain transforms AML1 (show RUNX1 Antibodies)-ETO into a potent leukemogenic protein

  10. p15(Ink4b (show CDKN2B Antibodies)) loss must be accompanied by additional oncogenic changes for RUNX1 (show RUNX1 Antibodies)-ETO-associated AML (show RUNX1 Antibodies) to develop

RUNX1T1 Antigen Profile

Protein Summary

This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8\;21)(q22\;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.

Gene names and symbols associated with RUNX1T1

  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (runx1t1) antibody
  • RUNX1 translocation partner 1 L homeolog (runx1t1.L) antibody
  • RUNX1 translocation partner 1 (RUNX1T1) antibody
  • runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (Runx1t1) antibody
  • RUNX1 translocation partner 1 (Runx1t1) antibody
  • AML1T1 antibody
  • Cbfa2t1 antibody
  • Cbfa2t1h antibody
  • CDR antibody
  • ETO antibody
  • MTG8 antibody
  • si:ch211-232j17.1 antibody
  • wu:fi14b07 antibody
  • zgc:154044 antibody
  • ZMYND2 antibody

Protein level used designations for RUNX1T1

protein CBFA2T1 , MTG8 , MTG8/ETOb , expressed during postmitotic spinal neurons, most likely in motorneurons , acute myelogenous leukemia 1 translocation 1, cyclin-D related , core-binding factor, runt domain, alpha subunit 2; translocated to, 1; cyclin D-related , eight twenty one protein , myeloid translocation gene on 8q22 , zinc finger MYND domain-containing protein 2 , CBFA2T1 identified gene homolog , acute myelogenous leukemia 1 translocation 1 protein , core-binding factor, runt domain, alpha subunit 2 , cyclin D-related , translocated to, 1

GENE ID SPECIES
767809 Danio rerio
733153 Xenopus laevis
395503 Gallus gallus
862 Homo sapiens
487044 Canis lupus familiaris
12395 Mus musculus
362489 Rattus norvegicus
100155449 Sus scrofa
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