anti-Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) Antibodies

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Additionally we are shipping SIGLEC10 Kits (27) and SIGLEC10 Proteins (8) and many more products for this protein.

list all antibodies Gene Name GeneID UniProt
SIGLEC10 89790 Q96LC7
SIGLEC10 292844  
SIGLEC10    
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Top anti-SIGLEC10 Antibodies at antibodies-online.com

Showing 10 out of 97 products:

Catalog No. Reactivity Host Conjugate Application Images Quantity Supplier Delivery Price Details
Dog Rabbit Un-conjugated WB WB Suggested Anti-SIGLEC10 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:1562500  Positive Control:  OVCAR-3 cell lysate 100 μL Log in to see 2 to 3 Days
$289.00
Details
Human Goat Un-conjugated BR, FACS, WB Detection of Siglec-10 in Human B Cells by Flow Cytometry. 100 μg Log in to see 8 to 9 Days
$416.30
Details
Human Rabbit Un-conjugated WB 50 μg Log in to see 11 to 14 Days
$551.83
Details
Human Rabbit Un-conjugated WB SIGLEC10 Antibody (ABIN650650) western blot analysis in Hela cell line lysates (35 µg/lane).This demonstrates the SIGLEC10 antibody detected the SIGLEC10 protein (arrow). Anti-SIGLEC10 Antibody at 1:1000 dilution + Daudi whole cell lysate Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 77 kDa Blocking/Dilution buffer: 5% NFDM/TBST. Dilution: 1:1000 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Goat PE FACS Detection of Siglec-10 in Human Blood Lymphocytes by Flow Cytometry. Human peripheral blood lymphocytes were stained with Mouse Anti-Human CD19 APC-conjugated Monoclonal Antibody. 100 Tests Log in to see 8 to 9 Days
$351.90
Details
Human Rabbit Un-conjugated WB SIGLEC10 Antibody (C-term)  western blot analysis in MCF-7 cell line lysates (35ug/lane).This demonstrates the SIGLEC10 antibody detected the SIGLEC10 protein (arrow). 400 μL Log in to see 10 to 11 Days
$335.50
Details
Human Rabbit Un-conjugated ICC, IHC, WB Used in DAB staining on fromalin fixed paraffin-embedded Ovary tissue 100 μg Log in to see 15 to 18 Days
$350.00
Details
Human Mouse PE FACS 100 Tests Log in to see 3 to 4 Days
$440.00
Details
Human Rabbit Un-conjugated WB SIGLEC10 antibody used at 1 ug/ml to detect target protein. 50 μg Log in to see 9 to 11 Days
$473.93
Details
Human Mouse PE IF, WB 100 Tests Log in to see 10 to 12 Days
$351.22
Details

Top referenced anti-SIGLEC10 Antibodies

  1. Human Monoclonal SIGLEC10 Primary Antibody for FACS - ABIN2476478 : Spiegelman, Israel, Bouchard, Willett: Absolute fat mass, percent body fat, and body-fat distribution: which is the real determinant of blood pressure and serum glucose? in The American journal of clinical nutrition 1992 (PubMed)
    Show all 4 Pubmed References

  2. Human Monoclonal SIGLEC10 Primary Antibody for FACS - ABIN2476476 : Munday, Kerr, Ni, Cornish, Zhang, Nicoll, Floyd, Mattei, Moore, Liu, Crocker: Identification, characterization and leucocyte expression of Siglec-10, a novel human sialic acid-binding receptor. in The Biochemical journal 2001 (PubMed)
    Show all 4 Pubmed References

  3. Human Monoclonal SIGLEC10 Primary Antibody for FACS - ABIN2476477 : Nguyen, Hurtado-Ziola, Gagneux, Varki: Loss of Siglec expression on T lymphocytes during human evolution. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Show all 4 Pubmed References

  4. Human Polyclonal SIGLEC10 Primary Antibody for BR, FACS - ABIN5012990 : Yokoi, Myers, Matsumoto, Crocker, Saito, Bochner: Alteration and acquisition of Siglecs during in vitro maturation of CD34+ progenitors into human mast cells. in Allergy 2006 (PubMed)
    Show all 2 Pubmed References

  5. Dog (Canine) Polyclonal SIGLEC10 Primary Antibody for WB - ABIN2784077 : Szafranski, Schindler, Taudien, Hiller, Huse, Jahn, Schreiber, Backofen, Platzer: Violating the splicing rules: TG dinucleotides function as alternative 3' splice sites in U2-dependent introns. in Genome biology 2008 (PubMed)

  6. Human Polyclonal SIGLEC10 Primary Antibody for FACS - ABIN4895910 : Madge, Maggioni, Pascolutti, Amin, Waespy, Bellette, Thomson, Kelm, von Itzstein, Haselhorst: Structural characterisation of high affinity Siglec-2 (CD22) ligands in complex with whole Burkitt's lymphoma (BL) Daudi cells by NMR spectroscopy. in Scientific reports 2016 (PubMed)

More Antibodies against SIGLEC10 Interaction Partners

Human Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) interaction partners

  1. soluble CD52 exerts a concerted immunosuppressive effect by first sequestering HMGB1 to nullify its proinflammatory Box B, followed by binding to the inhibitory Siglec-10 receptor, triggering recruitment of SHP1 to the intracellular immunoreceptor tyrosine-based inhibitory motif of Siglec-10 and its interaction with the TCR.

  2. Siglec-10 is associated with decreased survival and impaired NK cell function in human hepatocellular carcinoma (HCC (show FAM126A Antibodies)).

  3. Siglec-10-VAP-1 (show AOC3 Antibodies) interaction seems to mediate lymphocyte adhesion to endothelium

Pig (Porcine) Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) interaction partners

  1. Siglec-10 was demonstrated to be involved in the endocytosis of porcine reproductive and respiratory syndrome virus, confirming the important role of Siglec-10 in virus the entry process.

Mouse (Murine) Sialic Acid Binding Ig-Like Lectin 10 (SIGLEC10) interaction partners

  1. this study shows that Siglec-G inhibits dendritic cells cross-presentation by impairing such complex formation, and our results add insight into the regulation of cross-presentation in adaptive immunity

  2. The effect for Siglec-G deficiency in B cells results in higher B-1 cell numbers and a robust and preferential increase in oxidation-specific epitopes-specific IgM antibodies, which neutralize oxidized LDL-induced inflammation in vivo.

  3. Aging Siglec-G-deficient and Siglec-G 3/FcgammaRIIb double-deficient mice develop an autoimmune phenotype with elevated autoantibody levels and mild glomerulonephritis.

  4. Deficiency of SIGLEC-G was found to increase susceptibility to develop B-cell lymphoproliferative disorders.

  5. Siglec-G is recruited to the immunological synapse by sialic acid ligands on the Ag-bearing cells, producing a tolerogenic signal involving Lyn (show LYN Antibodies) and the proapoptotic factor BIM (show BCL2L11 Antibodies) that promotes deletion of the B cell and failure of mice to develop Abs to the Ag upon subsequent challenge.

  6. Siglec-G-CD24 (show CD24 Antibodies) axis, controls the severity of GVHD and suggest that enhancing this interaction may represent a novel strategy for mitigating GVHD.

  7. Siglec-G sialic acid-dependent binding to the BCR (show BCR Antibodies) is crucial for the B1 cell-restricted inhibitory function of Siglec-G and is regulated in an opposite way to that of the related protein CD22 (Siglec-2 (show CD22 Antibodies)) on B cells.

  8. Data indicate that the loss of the inhibitory receptor Siglec-G led to a moderate exacerbation of disease severity and early onset in both collagen-induced arthritis and spontaneous lupus nephritis in MRL/lpr (show FAS Antibodies) mice.

  9. Siglec-G inhibits B cell activation (show BLNK Antibodies) equally in both B1 & B2 subsets. It is expressed at a relatively constant level in numerous B cell subsets. It may maintain B cell tolerance toward self Ags (show GLA Antibodies) in various B cell compartments.

  10. Data reveal a negative feedback loop of RIG-I (show DDX58 Antibodies) signaling and identify a Siglec-G-mediated immune evasion pathway exploited by RNA viruses.

SIGLEC10 Antigen Profile

Protein Summary

SIGLECs are members of the immunoglobulin superfamily that are expressed on the cell surface. Most SIGLECs have 1 or more cytoplasmic immune receptor tyrosine-based inhibitory motifs, or ITIMs. SIGLECs are typically expressed on cells of the innate immune system, with the exception of the B-cell expressed SIGLEC6 (MIM 604405).

Gene names and symbols associated with SIGLEC10

  • sialic acid binding Ig like lectin 10 (SIGLEC10) antibody
  • sialic acid binding Ig-like lectin 10 (Siglec10) antibody
  • sialic acid-binding Ig-like lectin 10 (LOC484343) antibody
  • sialic acid-binding Ig-like lectin 10 (LOC100066644) antibody
  • sialic acid binding Ig-like lectin 10 (siglec10) antibody
  • sialic acid-binding Ig-like lectin 10 (LOC100513863) antibody
  • sialic acid-binding Ig-like lectin 10 (LOC100340374) antibody
  • sialic acid binding Ig like lectin 10 (Siglec10) antibody
  • pro940 antibody
  • siglec-10 antibody
  • SIGLEC10 antibody
  • Siglecg antibody
  • slg2 antibody

Protein level used designations for SIGLEC10

sialic acid binding Ig-like lectin 10 Ig-like lectin 7 , sialic acid-binding Ig-like lectin 10 , siglec-like gene 2 , siglec-like protein 2 , sialic acid binding Ig-like lectin G , sialic acid binding Ig-like lectin 10 , sialic acid-binding Ig-like lectin 10-like

GENE ID SPECIES
89790 Homo sapiens
292844 Rattus norvegicus
468977 Pan troglodytes
484343 Canis lupus familiaris
504258 Bos taurus
100066644 Equus caballus
100158511 Xenopus (Silurana) tropicalis
100478360 Ailuropoda melanoleuca
100513863 Sus scrofa
100595513 Nomascus leucogenys
100340374 Oryctolagus cuniculus
100713177 Cavia porcellus
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