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anti-Human AIM2 Antibodies:
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Human Polyclonal AIM2 Primary Antibody for IF, WB - ABIN522906
Fernandes-Alnemri, Yu, Datta, Wu, Alnemri: AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. in Nature 2009
Show all 4 Pubmed References
Human Monoclonal AIM2 Primary Antibody for ICC, WB - ABIN1169341
Cresswell, Clarke, Jackson, Darcy, Trapani, Johnstone: Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2. in Biochemical and biophysical research communications 2004
Show all 3 Pubmed References
Human Monoclonal AIM2 Primary Antibody for WB - ABIN1882191
Chen, Ou-Yang, Hung, Liu, Wang, Wang, Hou, Hortobagyi, Hung: AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model. in Molecular cancer therapeutics 2006
Show all 5 Pubmed References
Human Monoclonal AIM2 Primary Antibody for WB - ABIN1882206
DeYoung, Ray, Su, Anzick, Johnstone, Trapani, Meltzer, Trent: Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma. in Oncogene 1997
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Human Polyclonal AIM2 Primary Antibody for ELISA, IHC - ABIN4278860
Choubey, Duan, Dickerson, Ponomareva, Panchanathan, Shen, Srivastava: Interferon-inducible p200-family proteins as novel sensors of cytoplasmic DNA: role in inflammation and autoimmunity. in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2010
Show all 2 Pubmed References
Human Polyclonal AIM2 Primary Antibody for IP, WB - ABIN948806
Adamczak, de Rivero Vaccari, Dale, Brand, Nonner, Bullock, Dahl, Dietrich, Keane: Pyroptotic neuronal cell death mediated by the AIM2 inflammasome. in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2014
Mouse (Murine) Polyclonal AIM2 Primary Antibody for ELISA, WB - ABIN4252907
Wenzel, Wunderlich, Besch, Poeck, Willms, Schwantes, Kremer, Sutter, Endres, Schmidt, Rothenfusser: Cytosolic DNA triggers mitochondrial apoptosis via DNA damage signaling proteins independently of AIM2 and RNA polymerase III. in Journal of immunology (Baltimore, Md. : 1950) 2011
Overexpression of AIM2 in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cells suppressed mammalian target of rapamycin (mTOR (show FRAP1 Antibodies))-S6K1 (show RPS6KB1 Antibodies) pathway and further inhibited proliferation of HCC (show FAM126A Antibodies) cells.
AIM2 is an important component of the inflammasome in tegumentary leishmaniasis (TL) patients and is directly associated with the severity of lesions.
TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy.
AIM2 contributes to the maintenance of intestinal integrity via Akt (show AKT1 Antibodies) and protects against Salmonella mucosal infection.
study identifies the AIM2 inflammasome and cGAS/IFI16 (show IFI16 Antibodies)-STING-type I IFN pathway as a novel mechanism for host innate immunity to the ALVAC vaccine vector.
Study conclude that functional AIM2 is preferentially expressed in adult human CD27 (show CD27 Antibodies)+ B-cells, but is absent in cord blood mononuclear cells.
results suggest that the function of AIM2 is focused on the innate immune response, and AIM2 is a detrimental host factor for influenza-induced lung injury and mortality.
knockdown of AIM2 by small interfering RNA attenuated caspase-1 (show CASP1 Antibodies) activation. the results suggest that EBV infection of human monocytes induces caspase-1 (show CASP1 Antibodies)-dependent IL-1beta (show IL1B Antibodies) production, and that AIM2, acting as an inflammasome, is involved in this response.
These data indicate that human cytomegalovirus pUL83 interacts with human AIM2 in the cytoplasm during the early stages of virus infection. The pUL83/AIM2 interaction deregulates the activation of AIM2 inflammasome.
The findings reveal an age-dependent reduction of AIM2 expression and activation which may explain reduced cytokine responses to the cytosolic DNA mimic poly(dA:dT) in healthy elderly individuals. Reduced AIM2-mediated sensing with age may contribute to increased vulnerability to bacterial or viral infections in the elderly.
AIM2 cytosolic DNA sensor may conjugate competitively with cytosolic Mycobacterium bovis DNA to restrict Mycobacterium bovis induced STING-TBK1 (show TBK1 Antibodies)-dependent autophagy activation and IFN-beta (show IFNB1 Antibodies) secretion.
this study shows that aim2-like receptors are dispensable for the type I interferon (show IFNA Antibodies) response to transfected DNA ligands, DNA virus infection, and lentivirus infection
These results show for the first time that AIM2 plays an important anti-inflammatory, yet inflammasome-independent function in cardiomyocytes
These results demonstrate a central role for the AIM2 inflammasome in preventing dysbiosis and intestinal inflammation through regulation of the IL-18 (show IL18 Antibodies)/IL-22BP (show IL22RA2 Antibodies)/IL-22 (show IL22 Antibodies) and STAT3 (show STAT3 Antibodies) pathway
AIM2 senses radiation-induced DNA damage in the nucleus to mediate inflammasome activation and cell death.
Molecular docking analysis reveals that the conformation switching may be important for the autoinhibition of the AIM2 protein.
AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.
absent in melanoma 2
, interferon-inducible protein AIM2-like
, interferon-inducible protein AIM2
, interferon-inducible protein 210
, interferon-inducible protein p210