Browse our anti-AIM2 (AIM2) Antibodies

Human Absent in Melanoma 2 (AIM2) interaction partners

1. These results provide evidence for the role of AIM2 in the progression of cSCC (show CYP11A1 Antibodies) and identify AIM2 inflammasome function as a potential therapeutic target in these invasive and metastatic tumors.

2. RSAD2 and AIM2 Modulate Coxsackievirus A16 and Enterovirus A71 Replication in Neuronal Cells in Different Ways That May Be Associated with Their 5' Nontranslated Regions.

3. AIM2 inflammasome expression and activation is increased early during the course of acute pancreatitis, and suggests that AIM2 activation may affect systemic inflammation and organ failure in these patients

4. Overexpression of AIM2 in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cells suppressed mammalian target of rapamycin (mTOR (show FRAP1 Antibodies))-S6K1 (show RPS6KB1 Antibodies) pathway and further inhibited proliferation of HCC (show FAM126A Antibodies) cells.

5. AIM2 is an important component of the inflammasome in tegumentary leishmaniasis (TL) patients and is directly associated with the severity of lesions.

6. TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy.

7. AIM2 contributes to the maintenance of intestinal integrity via Akt (show AKT1 Antibodies) and protects against Salmonella mucosal infection.

8. study identifies the AIM2 inflammasome and cGAS/IFI16 (show IFI16 Antibodies)-STING-type I IFN pathway as a novel mechanism for host innate immunity to the ALVAC vaccine vector.

9. Study conclude that functional AIM2 is preferentially expressed in adult human CD27 (show CD27 Antibodies)+ B-cells, but is absent in cord blood mononuclear cells.

10. results suggest that the function of AIM2 is focused on the innate immune response, and AIM2 is a detrimental host factor for influenza-induced lung injury and mortality.

Mouse (Murine) Absent in Melanoma 2 (AIM2) interaction partners

1. This study found that Aim2 knockout mitigates Abeta (show APP Antibodies) deposition in the cerebral cortex and hippocampus of 5XFAD mice.

2. The AIM2 inflammasome amplifies signals of infection, triggering noncanonical activation of NLRP3 (show NLRP3 Antibodies). During infection, AIM2 and caspase-11 (show CASP4 Antibodies) induced membrane damage, which was sufficient and essential for activating the NLRP3 (show NLRP3 Antibodies) inflammasome.

3. AIM2 overexpression and inhibition were studied in ApoE (show APOE Antibodies)-/- mice that were fed a high-fat diet. The results showed that high fat diet increases the expression of AIM2.

4. These data provide evidence that the inflammasome components ASC (show STS Antibodies), NLRP3 (show NLRP3 Antibodies) and AIM2 play a role in regulating macrophage adhesion and activation in response to surface nanotopography and chemistry.

5. Thus, we demonstrated that AIM2 could promote the progression of atherosclerotic plaque by increasing migration in VSMCs.

6. AIM2 cytosolic DNA sensor may conjugate competitively with cytosolic Mycobacterium bovis DNA to restrict Mycobacterium bovis induced STING-TBK1 (show TBK1 Antibodies)-dependent autophagy activation and IFN-beta (show IFNB1 Antibodies) secretion.

7. TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy.

8. AIM2 contributes to the maintenance of intestinal integrity via Akt (show AKT1 Antibodies) and protects against Salmonella mucosal infection.

9. study identifies the AIM2 inflammasome and cGAS/IFI16 (show IFI16 Antibodies)-STING-type I IFN pathway as a novel mechanism for host innate immunity to the ALVAC vaccine vector.

10. results suggest that the function of AIM2 is focused on the innate immune response, and AIM2 is a detrimental host factor for influenza-induced lung injury and mortality.