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anti-Human AIM2 Antibodies:
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Human Polyclonal AIM2 Primary Antibody for IF, WB - ABIN522906
Fernandes-Alnemri, Yu, Datta, Wu, Alnemri: AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. in Nature 2009
Show all 4 Pubmed References
Human Monoclonal AIM2 Primary Antibody for WB - ABIN1882191
Chen, Ou-Yang, Hung, Liu, Wang, Wang, Hou, Hortobagyi, Hung: AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model. in Molecular cancer therapeutics 2006
Show all 5 Pubmed References
Human Monoclonal AIM2 Primary Antibody for WB - ABIN1882206
DeYoung, Ray, Su, Anzick, Johnstone, Trapani, Meltzer, Trent: Cloning a novel member of the human interferon-inducible gene family associated with control of tumorigenicity in a model of human melanoma. in Oncogene 1997
Show all 5 Pubmed References
Human Monoclonal AIM2 Primary Antibody for ICC, WB - ABIN1169341
Cresswell, Clarke, Jackson, Darcy, Trapani, Johnstone: Biochemical and growth regulatory activities of the HIN-200 family member and putative tumor suppressor protein, AIM2. in Biochemical and biophysical research communications 2004
Show all 3 Pubmed References
Human Polyclonal AIM2 Primary Antibody for ELISA, IHC - ABIN4278860
Choubey, Duan, Dickerson, Ponomareva, Panchanathan, Shen, Srivastava: Interferon-inducible p200-family proteins as novel sensors of cytoplasmic DNA: role in inflammation and autoimmunity. in Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2010
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Human Polyclonal AIM2 Primary Antibody for IP, WB - ABIN948806
Adamczak, de Rivero Vaccari, Dale, Brand, Nonner, Bullock, Dahl, Dietrich, Keane: Pyroptotic neuronal cell death mediated by the AIM2 inflammasome. in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 2014
Mouse (Murine) Polyclonal AIM2 Primary Antibody for ELISA, WB - ABIN4252907
Wenzel, Wunderlich, Besch, Poeck, Willms, Schwantes, Kremer, Sutter, Endres, Schmidt, Rothenfusser: Cytosolic DNA triggers mitochondrial apoptosis via DNA damage signaling proteins independently of AIM2 and RNA polymerase III. in Journal of immunology (Baltimore, Md. : 1950) 2011
These results provide evidence for the role of AIM2 in the progression of cSCC (show CYP11A1 Antibodies) and identify AIM2 inflammasome function as a potential therapeutic target in these invasive and metastatic tumors.
RSAD2 and AIM2 Modulate Coxsackievirus A16 and Enterovirus A71 Replication in Neuronal Cells in Different Ways That May Be Associated with Their 5' Nontranslated Regions.
AIM2 inflammasome expression and activation is increased early during the course of acute pancreatitis, and suggests that AIM2 activation may affect systemic inflammation and organ failure in these patients
Overexpression of AIM2 in hepatocellular carcinoma (HCC (show FAM126A Antibodies)) cells suppressed mammalian target of rapamycin (mTOR (show FRAP1 Antibodies))-S6K1 (show RPS6KB1 Antibodies) pathway and further inhibited proliferation of HCC (show FAM126A Antibodies) cells.
AIM2 is an important component of the inflammasome in tegumentary leishmaniasis (TL) patients and is directly associated with the severity of lesions.
TRIM11 suppresses AIM2 inflammasome by degrading AIM2 via p62-dependent selective autophagy.
AIM2 contributes to the maintenance of intestinal integrity via Akt (show AKT1 Antibodies) and protects against Salmonella mucosal infection.
study identifies the AIM2 inflammasome and cGAS/IFI16 (show IFI16 Antibodies)-STING-type I IFN pathway as a novel mechanism for host innate immunity to the ALVAC vaccine vector.
Study conclude that functional AIM2 is preferentially expressed in adult human CD27 (show CD27 Antibodies)+ B-cells, but is absent in cord blood mononuclear cells.
results suggest that the function of AIM2 is focused on the innate immune response, and AIM2 is a detrimental host factor for influenza-induced lung injury and mortality.
This study found that Aim2 knockout mitigates Abeta (show APP Antibodies) deposition in the cerebral cortex and hippocampus of 5XFAD mice.
The AIM2 inflammasome amplifies signals of infection, triggering noncanonical activation of NLRP3 (show NLRP3 Antibodies). During infection, AIM2 and caspase-11 (show CASP4 Antibodies) induced membrane damage, which was sufficient and essential for activating the NLRP3 (show NLRP3 Antibodies) inflammasome.
AIM2 overexpression and inhibition were studied in ApoE (show APOE Antibodies)-/- mice that were fed a high-fat diet. The results showed that high fat diet increases the expression of AIM2.
These data provide evidence that the inflammasome components ASC (show STS Antibodies), NLRP3 (show NLRP3 Antibodies) and AIM2 play a role in regulating macrophage adhesion and activation in response to surface nanotopography and chemistry.
Thus, we demonstrated that AIM2 could promote the progression of atherosclerotic plaque by increasing migration in VSMCs.
AIM2 cytosolic DNA sensor may conjugate competitively with cytosolic Mycobacterium bovis DNA to restrict Mycobacterium bovis induced STING-TBK1 (show TBK1 Antibodies)-dependent autophagy activation and IFN-beta (show IFNB1 Antibodies) secretion.
AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2.
absent in melanoma 2
, interferon-inducible protein AIM2-like
, interferon-inducible protein AIM2
, interferon-inducible protein 210
, interferon-inducible protein p210