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These results strongly suggest that AMPK can activate ORP150 (show HYOU1 Proteins) through FOXO1 (show FOXO1 Proteins) pathway and confer protection against endoplasmic reticulum stress - induced apoptosis of airway epithelial cells following exposure to cigarette smoke extract.
These findings revealed that prosurvival autophagy was one of the mechanisms involved in the resistance acute myeloid leukemia (show BCL11A Proteins) (AML (show RUNX1 Proteins)) leukemia stem cells to JQ1. Targeting the AMPK/ULK1 (show ULK1 Proteins) pathway or inhibition of autophagy could be an effective therapeutic strategy for combating resistance to BET inhibitors in AML (show RUNX1 Proteins) and other types of cancerof cancer
These findings collectively indicate that ALR (show GFER Proteins) negatively regulates the autophagy process through an association with the AMPK/mTOR (show FRAP1 Proteins) signaling pathway. Autophagy inhibit apoptosis and play a protective role under conditions of oxidative stress.
Our data indicated that miR (show MLXIP Proteins)-451 relays environmental signals by upregulating the activity of AMPK signaling, thereby modulating the activation of mTOR (show FRAP1 Proteins) and Rac1/cofilin (show CFL1 Proteins) which, in turn, play key roles in glioma cell proliferation and migration, respectively. Our results highlight the need to consider opposing roles of a therapeutic target which, while suppressing tumor cell proliferation, could also promote cell infiltratio
Data show that miR (show MLXIP Proteins)-135b selectively targets the AMPK phosphatase Ppm1e (show PPM1E Proteins).
We found that activation of AMPK by all fluorinated N,N-diarylureas (FND) compounds at micromolar levels significantly inhibited the cell-cycle progression and subsequent cellular proliferation.
Our data suggest that AMPK regulates ATM (show ATM Proteins) expression and partially regulates radiosensitivity under hypoxia and nutrient starvation. The molecular mechanism underlying the induction of ATM (show ATM Proteins) expression by AMPK remains to be elucidated.
These results suggest that berberine-induced activation of AMPK may contribute to hepatic FGF21 (show FGF21 Proteins) expression via NUR77 (show NR4A1 Proteins).
AMPK enhances intestinal barrier function and epithelial differentiation via promoting CDX2 (show CDX2 Proteins) expression, which is partially mediated by altered histone modifications in the Cdx2 (show CDX2 Proteins) promoter.
activation of AMPK upregulated Smad6 (show SMAD6 Proteins) and Smurf1 (show SMURF1 Proteins) and thereby enhanced their interactions, resulting in its proteosome-dependent degradation of ALK2 (show ACRV1 Proteins).
Endometrial inflammatory responses to lipopolysaccharide were also reduced by small molecules that activate or inhibit the intracellular sensor of energy, AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)).
The results suggest that activation of AMPK represses global protein synthesis in mammary epithelial cells through inhibition of mTORC1 signaling.
Nitrated oleic acid activates AMPK in endothelial cells.
Findings suggest that ischemic factor stimulation of the blood brain barrier Na-K-Cl cotransporter (show SLC12A1 Proteins) involves activation of AMPK.
Results suggest that mitochondria-derived superoxide anions and peroxynitrite are required for Berberine-induced AMPK activation in endothelial cells.
the expression, but not the kinase activity, of AMPK and CaMKKbeta is necessary for ADP signaling to eNOS (show NOS3 Proteins)
AMPK-related pathways may be compromised during fluoxetine exposure as a result of increased miRNA abundance.
Klotho (show KL Proteins) gene deficiency promotes high-fat diet-induced fibrosis in aortic valves, likely through the AMPKalpha (show GRK4 Proteins)-RUNX2 (show RUNX2 Proteins) pathway.
AMPK-mTOR (show FRAP1 Proteins)-autophagy signaling is altered by intrauterine growth restriction in newborn piglets.
Data indicate that 17beta-estradiol reduced Sertoli Cell proliferation by inhibiting microRNA miR (show MYLIP Proteins)-1285 and thus activating AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)).
L-Glutamine enhances enterocyte growth but did not affect abundances of total or phosphorylated AMPK protein.
AMPK activity plays an important role in the maintenance of the spermatozoa quality during long-term storage of boar semen.
AMPK, lying downstream of PKA, regulates at different levels mammalian spermatozoa membrane function.
Porcine circovirus type 2 (PCV2) might induce autophagy via the AMPK/ERK (show MAPK1 Proteins)/TSC2/mTOR (show FRAP1 Proteins) signaling pathway in the host cells, representing a pivotal mechanism for PCV2 pathogenesis
AMPK deficiency or inhibition attenuated or mitigated ethanol exposure-triggered glucose intolerance and compromised cardiac contraction by increased phosphorylation of AMPK and acetyl-CoA carboxylase as well as autophagosome accumulation.
AMPK functions to inhibit IGF-I (show IGF1 Proteins)-stimulated PI3K pathway activation through stimulation of IRS-1 (show IRS1 Proteins) serine 794 phosphorylation.
acute activation of AMPK increases intestinal glucose absorption after administration of long-chain n-3 polyunsaturated fatty acids during gestation
Cardiac SUR2A (show ABCC9 Proteins) levels were significantly increased while Kir6.2 (show KCNJ11 Proteins) levels were not affected. Hypoxia did not induce phosphorylation of extracellular signal-regulated kinases (ERK1/2) or protein kinase B (Akt (show AKT1 Proteins)), but triggered phosphorylation of AMP activated protein kinase (AMPK (show PRKAA2 Proteins)). AICAR (show ATIC Proteins), an activator of AMPK, increased the level of SUR2A (show ABCC9 Proteins) in H9c2 cells. We conclude that oxygen increases SUR2A (show ABCC9 Proteins) level by activating AMPK.
This study provides new insights into the control of eEF2K (show EEF2K Proteins) by AMPK.
These data indicate that a reduction in AMPK disrupts cellular metabolism in both progenitors and differentiated placental trophoblasts.
Inhibition of NAMPT (show NAMPT Proteins) aggravates high fat diet-induced hepatic steatosis in mice through regulating Sirt1 (show SIRT1 Proteins)/AMPKalpha (show GRK4 Proteins)/SREBP1 (show SREBF1 Proteins) signaling pathway.
Targeted activation of AMPK by GSK621 ameliorates H2O2-induced osteoblast cell injuries.
Sestrin 1 (show SESN1 Proteins) targets at the AMPK/mTORC1/autophagy pathway to inhibit cardiac hypertrophy by interaction with AMPK which is responsible for autophagy regulation. Taken together, our data indicate that Sestrin 1 (show SESN1 Proteins) regulates AMPK/mTORC1/autophagy axis to attenuate cardiac hypertrophy.
our results elucidate a previously unrecognized role of AMPKalpha1 deletion in loss of contact inhibition of cellular proliferation and angiogenesis
AMPK and Sirt2 (show SIRT2 Proteins) control compensatory glucose uptake in metabolically arrested mitochondria.
AMP-activated protein kinase (AMPK (show PRKAA2 Proteins)) regulates autophagy by phosphorylating BECN1 (show BECN1 Proteins) at Thr388
Constitutively active AMPKgammaR70Q significantly decreases Napi-IIa oocyte cell membrane abundance, an effect not mimicked by catalytically-inactive AMPKalphaK45R.
NDPK-A (show NME1 Proteins) exists in a functional cellular complex with AMPK (show PRKAA2 Proteins) and CFTR (show CFTR Proteins) in airway epithelia, and NDPK-A (show NME1 Proteins) catalytic function is required for the AMPK (show PRKAA2 Proteins)-dependent regulation of CFTR (show CFTR Proteins)
The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP-consuming biosynthetic pathways. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
5'-AMP-activated protein kinase catalytic subunit alpha-1
, 5'-AMP-activated protein kinase, catalytic alpha-1 chain
, ACACA kinase
, AMP -activate kinase alpha 1 subunit
, AMP-activated protein kinase, catalytic, alpha-1
, AMPK alpha 1
, AMPK subunit alpha-1
, HMGCR kinase
, acetyl-CoA carboxylase kinase
, hydroxymethylglutaryl-CoA reductase kinase
, tau-protein kinase PRKAA1
, 5'-AMP-activated protein kinase alpha-1 catalytic subunit
, 5'-AMP-activated protein kinase alpha 1 catalytic subunit
, 63 kDa subunit
, AMPK 63 kDa subunit
, AMPK alpha-1 chain
, AMP-activated protein kinase, alpha 1 catalytic subunit
, 5'-AMP-activated protein kinase catalyti subunit alpha-1-like protein
, AMPK-activated protein kinase alpha-1 subunit
, protein kinase, AMP-activated, alpha 1 catalytic subunit