FLT3 antibody (N-Term)

Catalog No. ABIN1077372

This anti-FLT3 antibody is a Rabbit Polyclonal antibody detecting FLT3 in WB, ELISA and IF. Suitable for Human and Mouse.

Quick Overview for FLT3 antibody (N-Term) (ABIN1077372)

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This FLT3 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Product Details anti-FLT3 Antibody

Binding Specificity: N-Term

Specificity: At least three isoforms of FLT3 are known to exist, this antibody will detect all isoforms.

Purification: Affinity chromatography purified via peptide column

Immunogen: FLT3 antibody was raised against an 18 amino acid synthetic peptide near the center of human FLT3.

Isotype: IgG

Application Details

Application Notes: FLT3 antibody can be used for detection of FLT3 by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.

Comment:

(NT) Fms-like tyrosine kinase 3

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C

Storage Comment: FLT3 antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.

Expiry Date: 12 months

Target Details for FLT3

Target: FLT3 (Fms-Related tyrosine Kinase 3 (FLT3))

Alternative Name: FLT3

Background: FLT3 is a member of the class III receptor tyrosine kinase family and its internal tandem duplication (ITD) is preferentially seen in acute myeloid leukemia and myelodysplastic syndrome among various hematological malignancies. It is a membrane bound glycosylated protein that is expressed primarily in early hematopoietic progenitor cells. Upon binding its ligand FL, FLT3 activates multiple signaling pathways including the PI3K/Akt and Ras/MEK/MAPK pathways. In cells expressing FLT3-ITD, these pathways are constitutively on, resulting in abnormal cell growth and anti-apoptotic activity.
Synonyms: Fms-like tyrosine kinase 3, receptor-type tyrosine-protein kinase FLT3, CD135, FL cytokine receptor, fetal liver kinase 2, stem cell tyrosine kinase 1

Molecular Weight: 109 kDa

Gene ID: 2322

NCBI Accession: NP_004110

Pathways: RTK Signaling