Casein Kinase 2, alpha Prime Polypeptide (CSNK2A2) (AA 194-350) antibody

Details for Product No. ABIN1098114
Antigen
Epitope
AA 194-350
9
8
7
7
5
4
3
2
1
1
1
1
Reactivity
Human, Mouse (Murine)
84
37
23
5
5
5
4
4
3
2
2
1
1
Host
Mouse
76
8
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
7
5
5
2
2
2
2
2
2
2
2
2
Application
Flow Cytometry (FACS), ELISA, Western Blotting (WB)
64
46
23
6
6
5
4
2
Options
Immunogen Purified recombinant fragment of human CSNK2A2 (AA 194-350) expressed in E. Coli.
Clone 1-00E-01
Isotype IgG1
Purification Ascites
Antigen
Alternative Name CSNK2A2 (CSNK2A2 Antibody Abstract)
Background Casein kinase II (CK2) is a constitutively active, ubiquitously expressed serine/threonine protein kinase that is thought to have a regulatory function in cell proliferation, cell differentiation and apoptosis. CK2 functions as a tetrameric complex consisting of two regulatory beta-subunits and two catalytic units (alpha and alpha') in a homomeric or heteromeric conformation. Whilst the alpha- and alpha'-subunits are catalytically identical, proteins that regulate CK2, such as cdc2 and Hsp90, preferentially bind to the alpha and not the alpha'-subunit. CK2 can phosphorylate a number of key intracellular signaling proteins implicated in tumor suppression (p53 and PTEN) and tumorigenesis (myc, jun, NF-kappaB). CK2 is also thought to influence Wnt signaling via beta-catenin phosphorylation and the PI 3-K signaling pathway via the phosphorylation of Akt.
Molecular Weight 41.2 kDa
Gene ID 1459
HGNC 1459
Pathways SARS-CoV-2 Protein Interactome
Application Notes ELISA: 1:10000, WB: 1:500 - 1:2000, FCM: 1:200 - 1:400
Restrictions For Research Use only
Format Liquid
Buffer Ascitic fluid containing 0.03 % sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C,-20 °C
Storage Comment 4°C, -20°C for long term storage
Supplier Images
Image no. 1 for anti-Casein Kinase 2, alpha Prime Polypeptide (CSNK2A2) (AA 194-350) antibody (ABIN1098114) Figure 1: Red: Control Antigen (100 ng), Purple: Antigen (10ng), Green: Antigen (50 n...
Image no. 2 for anti-Casein Kinase 2, alpha Prime Polypeptide (CSNK2A2) (AA 194-350) antibody (ABIN1098114) Figure 2: Flow cytometric analysis of HepG2 cells using CSNK2A2 mouse mAb (green) and...
Image no. 3 for anti-Casein Kinase 2, alpha Prime Polypeptide (CSNK2A2) (AA 194-350) antibody (ABIN1098114) Figure 3: Western blot analysis using CSNK2A2 mouse mAb against HeLa (1), MCF-7 (2), ...
Image no. 4 for anti-Casein Kinase 2, alpha Prime Polypeptide (CSNK2A2) (AA 194-350) antibody (ABIN1098114) Figure 4: Western blot analysis using CSNK2A2 mAb against human CSNK2A2 recombinant p...
Product cited in: Chemnitz, Pieper, Grüttner, Hauber: "Phosphorylation of the HuR ligand APRIL by casein kinase 2 regulates CD83 expression." in: European journal of immunology, Vol. 39, Issue 1, pp. 267-79, 2009 (PubMed).

Schäfer, Götz, Dudek, Hessenauer, Matti, Montenarh: "KIF5C: a new binding partner for protein kinase CK2 with a preference for the CK2alpha' subunit." in: Cellular and molecular life sciences : CMLS, Vol. 66, Issue 2, pp. 339-49, 2009 (PubMed).