Prosaposin antibody (AA 325-524)

Catalog No. ABIN1098150

This anti-Prosaposin antibody is a Mouse Monoclonal antibody detecting Prosaposin in IHC, ELISA, ICC and FACS. Suitable for Human. This Primary Antibody has been cited in 2+ publications.

Quick Overview for Prosaposin antibody (AA 325-524) (ABIN1098150)

Target: Prosaposin (PSAP)

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This Prosaposin antibody is un-conjugated

Application: Immunohistochemistry (IHC), ELISA, Immunocytochemistry (ICC), Flow Cytometry (FACS)

Clone: 4D5F4

Product Details anti-Prosaposin Antibody

Binding Specificity: AA 325-524

Purpose: PSAP Antibody

Purification: Purified antibody

Immunogen: Purified recombinant fragment of human PSAP (AA: 325-524 ) expressed in E. Coli.

Isotype: IgG1

Application Details

Application Notes:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/50 - 1/500

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

References for anti-Prosaposin antibody (ABIN1098150)

Xu, Deng, Mao, Zhang, Wang, Wang, Mu, Deng, Ma: "The interaction of the second Kunitz-type domain (KD2) of TFPI-2 with a novel interaction partner, prosaposin, mediates the inhibition of the invasion and migration of human fibrosarcoma cells." in: The Biochemical journal, Vol. 441, Issue 2, pp. 665-74, (2011) (PubMed).

Hu, Delorme, Liu, Liu, Velasco-Gonzalez, Garai, Pullikuth, Koochekpour: "Prosaposin down-modulation decreases metastatic prostate cancer cell adhesion, migration, and invasion." in: Molecular cancer, Vol. 9, pp. 30, (2010) (PubMed).

Target Details for Prosaposin

Target: Prosaposin (PSAP)

Alternative Name: PSAP

Background: This gene encodes a highly conserved glycoprotein which is a precursor for 4 cleavage products: saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease, Tay-Sachs disease, and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molecular Weight: 58.1 kDa

UniProt: P07602

Pathways: Positive Regulation of Endopeptidase Activity