Prosaposin antibody (AA 60-310)

Catalog No. ABIN3022606

This Rabbit Polyclonal antibody specifically detects Prosaposin in WB, IHC and IF. It exhibits reactivity toward Human.

Quick Overview for Prosaposin antibody (AA 60-310) (ABIN3022606)

Target: Prosaposin (PSAP)

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Prosaposin antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-Prosaposin Antibody

Binding Specificity: AA 60-310

Sequence: SLPCDICKDV VTAAGDMLKD NATEEEILVY LEKTCDWLPK PNMSASCKEI VDSYLPVILD IIKGEMSRPG EVCSALNLCE SLQKHLAELN HQKQLESNKI PELDMTEVVA PFMANIPLLL YPQDGPRSKP QPKDNGDVCQ DCIQMVTDIQ TAVRTNSTFV QALVEHVKEE CDRLGPGMAD ICKNYISQYS EIAIQMMMHM QPKEICALVG FCDEVKEMPM QTLVPAKVAS KNVIPALELV EPIKKHEVPA K

Cross-Reactivity: Human, Mouse, Rat

Characteristics: Polyclonal Antibodies

Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 60-310 of human PSAP (NP_002769.1).

Isotype: IgG

Application Details

Application Notes: WB,1:500 - 1:2000,IHC,1:50 - 1:200,IF,1:50 - 1:200

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: PBS with 0.02 % sodium azide,50 % glycerol, pH 7.3.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid freeze / thaw cycles

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze / thaw cycles.

Target Details for Prosaposin

Target: Prosaposin (PSAP)

Alternative Name: PSAP

Background: This gene encodes a highly conserved preproprotein that is proteolytically processed to generate four main cleavage products including saposins A, B, C, and D. Each domain of the precursor protein is approximately 80 amino acid residues long with nearly identical placement of cysteine residues and glycosylation sites. Saposins A-D localize primarily to the lysosomal compartment where they facilitate the catabolism of glycosphingolipids with short oligosaccharide groups. The precursor protein exists both as a secretory protein and as an integral membrane protein and has neurotrophic activities. Mutations in this gene have been associated with Gaucher disease and metachromatic leukodystrophy. Alternative splicing results in multiple transcript variants, at least one of which encodes an isoform that is proteolytically processed.,PSAP,GLBA,SAP1,Cancer,Signal Transduction,Endocrine & Metabolism,Lipid Metabolism,PSAP

Molecular Weight: 58 kDa

Gene ID: 5660

UniProt: P07602

Pathways: Positive Regulation of Endopeptidase Activity