beta Amyloid antibody (C-Term)

Catalog No. ABIN1105356

This anti-beta Amyloid antibody is a Mouse Monoclonal antibody detecting beta Amyloid in WB and EIA. Suitable for Human, Mouse, Rat and Primate.

Quick Overview for beta Amyloid antibody (C-Term) (ABIN1105356)

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Reactivity: Human, Mouse, Rat, Primate

Host: Mouse

Clonality: Monoclonal

Conjugate: This beta Amyloid antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: CA9 3B3

Product Details anti-beta Amyloid Antibody

Binding Specificity: C-Term

Sequence: MVGGVVIA

Specificity: This antibody recognizes the C-terminal sequence of beta amyloid peptide 42 and full length beta amyloid peptide 42. The antibody does not cross react with beta amyloid peptide 40 in dot blotting and ELISA. Cross-reactivity to beta amyloid peptide 43 is about 5 % in ELISA.

Cross-Reactivity (Details): Species reactivity (tested):Human, Primates, Mouse, Rat.

Purification: Protein G affinity purified

Immunogen: KLH conjugated to a short peptide with amino acid sequence corresponding to the C- terminal of beta amyloid peptide 42.

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Restore with Double distillated water to adjust the final concentration to 1.0 mg/mL.

Buffer: 0.01 M PBS pH 7.2

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20 °C.

Target Details for beta Amyloid

Target: beta Amyloid (Abeta) (Amyloid beta (Abeta))

Alternative Name: Amyloid beta

Background: Amyloid beta peptide 42 (Aβ42) is best known for its role in the formation of senile plaques in the brain of patients with Alzheimer's disease. Aβ42 and Aβ40 are the two major amyloid peptides that are produced after cleavage of amyloid precursor protein by secretases. Aβ42 (42 amino acids) is very fibrillogenic. The beta pleated structure of Aβ42 constituents the initial and key component of the insoluble amyloid fibril in senile plaque. It is widely accepted that Aβ42 contributes to the pathogenesis of Alzheimer's disease. One proposition is that the deposition of amyloid fibril onto the brain tissue results in Alzheimer's disease. Another is that the neurotoxicity of Aβ42 oligomer is the cause of the disease.Synonyms: Amyloid beta peptide

Gene ID: 351

Pathways: Inflammasome