CD46 antibody

Catalog No. ABIN1106417

The Mouse Monoclonal anti-CD46 antibody has been validated for WB, IP, Func and EIA. It is suitable to detect CD46 in samples from Human.

Quick Overview for CD46 antibody (ABIN1106417)

Target: CD46

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD46 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Functional Studies (Func), Enzyme Immunoassay (EIA)

Clone: M177

Product Details anti-CD46 Antibody

Specificity: The monoclonal antibody M177 recognizes CD46, also designated membrane cofactor protein (MCP).

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein G

Immunogen: Purified MCP

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % bovine serum albumin

Storage: 4 °C

Storage Comment: Store at 2 - 8 °C.

Target Details for CD46

Target: CD46

Alternative Name: CD46 / MCP

Background: CD46 is a 45-70 kDa protein with genetic and tissue-specific heterogeneity. It is expressed on every cell and tissue, with the exception of erythrocytes. CD46 serves to inhibit complement activation on host tissue. It performs this function by serving as a cofactor which binds to C3b and C4b. This binding is permitted by factor I, a serine protease of plasma, to degrade C3b and C4b and serves to protect the host cell against autologous attack. It also serves as a receptor for measles virus. Four isoforms of CD46 predominate and arise by alternative splicing of a single CD46 gene. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR).Synonyms: MIC10, Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen

Gene ID: 4179

NCBI Accession: NP_002380

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization