CEP290 antibody (C-Term)

Catalog No. ABIN1106670

This anti-CEP290 antibody is a Rabbit Polyclonal antibody detecting CEP290 in WB, IHC (fro) and EIA. Suitable for Human, Mouse and Rat.

Quick Overview for CEP290 antibody (C-Term) (ABIN1106670)

Target: CEP290 (Centrosomal Protein 290kDa (CEP290))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CEP290 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Product Details anti-CEP290 Antibody

Binding Specificity: C-Term

Specificity: Reacts with Mouse 290 kDa Cep290 protein.

Cross-Reactivity (Details): Species reactivity (expected):Rat, Human.
Species reactivity (tested):Mouse.

Purification: Affinity Chromatography on Protein A

Immunogen: Synthetic peptide derived from C-terminal domain of Mouse Cep290.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Restore in distilled water.

Buffer: 0.1 M Tris, 0.1 M Glycine and 2 % Sucrose, None

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Prior to reconstitution store the antibody at -20 °C. Store reconstituted antibody at 2-8 °C for one month or (in aliquots) at -20 °C for longer

Target Details for CEP290

Target: CEP290 (Centrosomal Protein 290kDa (CEP290))

Alternative Name: CEP290

Background: CEP290 activates ATF4 mediated transcription and is required for the correct localization of ciliary and phototransduction proteins in retinal photoreceptor cells, may play a role in ciliary transport processes. CEP290 is ubiquitously expressed, strongly in placenta and weakly in brain. There are two named isoforms. Defects in CEP290 are a cause of Joubert syndrome type 5 (JBTS5) [MIM:610188], Senior-Loken syndrome type 6 (SLSN6) [MIM:610189], Leber congenital amaurosis type 10 (LCA10) [MIM:611755] and Meckel syndrome type 4 (MKS4) [MIM:611134]. Antibodies against CEP290 are present in sera from patients with cutaneous T cell lymphomas, but not in the healthy control population.Synonyms: CT87, Cancer/testis antigen 87, Centrosomal protein of 290 kDa, KIAA0373, NPHP6, Nephrocystin-6, Tumor antigen se2-2, se2-2

Gene ID: 216274

NCBI Accession: NP_666121

Pathways: cAMP Metabolic Process, M Phase