CEP290 antibody (AA 740-820)

Catalog No. ABIN7214146

This Rabbit Polyclonal antibody specifically detects CEP290 in ELISA and WB. It exhibits reactivity toward Human and Mouse.

Quick Overview for CEP290 antibody (AA 740-820) (ABIN7214146)

Target: CEP290 (Centrosomal Protein 290kDa (CEP290))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CEP290 antibody is un-conjugated

Application: ELISA, Western Blotting (WB)

Product Details anti-CEP290 Antibody

Binding Specificity: AA 740-820

Purpose: Rabbit Anti-CEP290 Polyclonal Antibody

Specificity: CEP290 Polyclonal Antibody detects endogenous levels of CEP290 protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the Internal region of human CEP290 at AA range: 740-820

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,ELISA 1:20000,Not yet tested in other applications.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for CEP290

Target: CEP290 (Centrosomal Protein 290kDa (CEP290))

Alternative Name: CEP290

Background: CEP290, BBS14, KIAA0373, NPHP6, Centrosomal protein of 290 kDa, Cep290, Bardet-Biedl syndrome 14 protein, Cancer/testis antigen 87, CT87, Nephrocystin-6, Tumor antigen se2-2CEP290 encodes a protein (centrosomal protein 290) with 13 putative coiled-coil domains, a region with homology to SMC chromosome segregation ATPases, six KID motifs, three tropomyosin homology domains and an ATP/GTP binding site motif A. The protein is localized to the centrosome and cilia and has sites for N-glycosylation, tyrosine sulfation, phosphorylation, N-myristoylation, and amidation. Mutations in CEP290 have been associated with Joubert syndrome and nephronophthisis and the presence of antibodies against this protein is associated with several forms of cancer.

Molecular Weight: 290kD

Gene ID: 80184

UniProt: O15078

Pathways: cAMP Metabolic Process, M Phase