RCAS1 antibody

Catalog No. ABIN1107048

The Mouse Monoclonal anti-RCAS1 antibody (Clone 22-01-01) (ABIN1107048) specifically detects RCAS1 in IHC (p) and FACS. The antibody is reactive with Human samples.

Quick Overview for RCAS1 antibody (ABIN1107048)

Target: RCAS1 (EBAG9) (Estrogen Receptor Binding Site Associated, Antigen, 9 (EBAG9))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This RCAS1 antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Clone: 22-01-01

Product Details anti-RCAS1 Antibody

Specificity: This antibody recognizes RCAS1.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein-L Sepharose

Immunogen: Human uterine cervical adenocarcinoma cell

Isotype: IgM

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Buffer: 100 μg IgG in 100 μLvolukme of PBS containing 50 % glycerol and 0.5 M NaCl, pH 7.2 No preservative is contained.

Preservative: Azide free

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store (in aliquots) at -20 °C.

Target Details for RCAS1

Target: RCAS1 (EBAG9) (Estrogen Receptor Binding Site Associated, Antigen, 9 (EBAG9))

Alternative Name: EBAG9 / RCAS1

Background: RCAS1 (receptor-binding cancer antigen expressed on SiSo cells) is a novel tumoreassociated antigen expressed in human uterine and ovarian carcinomas. The predicted amino acid sequence of RCAS1 (213 a.a.) possesses an N-terminal transmembrane region and a coiled-coil structure in the C-terminal portion, indicating that RCAS1 is a type II membrane protein able to form oligomers through the coiled-coil structure. RCAS1 revealed different expression pattern from the known tumore associated antigens such as, YH206, GA733, CA125, CEA and sialyl Le molecules in human tumore cell lines. Recent study indicated RCAS1 acts as a ligand for a putative receptor present on various human cells including T, B and NK cells. RCAS1 inhibited the in vitro growth of receptor-expressing cells and induced apoptosis. It was suggested that tumore cells might evade immune surveillance by expression of RCAS1.Synonyms: Cancer-associated surface antigen RCAS1, EB9, Estrogen receptor-binding fragment-associated gene 9 protein, PDAF, Receptor-binding cancer antigen expressed on SiSo cells

Gene ID: 9166

NCBI Accession: NP_004206

UniProt: O00559