HES1 antibody

Catalog No. ABIN1107520

This Mouse Monoclonal antibody specifically detects HES1 in WB and EIA. It exhibits reactivity toward Human.

Quick Overview for HES1 antibody (ABIN1107520)

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This HES1 antibody is un-conjugated

Application: Western Blotting (WB), Enzyme Immunoassay (EIA)

Clone: 7C2g2

Product Details anti-HES1 Antibody

Specificity: Reacts with Human 30 kDa HES-1 protein. May cross react with Mouse and Rat.

Purification: Affinity Chromatography on Protein A

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Reconstitution: Restore in distilled water.

Buffer: 0.1 M Tris, 0.1 M Glycine and 2 % Sucrose, None

Target Details for HES1

Target: HES1 (Hes Family bHLH Transcription Factor 1 (HES1))

Alternative Name: HES1

Background: HES1 is a nuclear protein belonging to th basic helix-loop-helix family of transcription factors with a basic helix-loop-helix (bHLH) domain and an Orange domain. The basic domain of HES1 contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. An immediate early response gene to growth factor, HES1 is reported as having a dual function of both transcriptional activator and silencer of acid alpha-glucosidase (GAA), thus contributing to the subtle tissue-specific control of housekeeping genes such as GAA. HES1 a transcriptional repressor of genes which require a bHLH protein for their transcription and also the formation of a complex with a corepressor protein (Groucho) such as TLE2. HES1 may act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1.Synonyms: HES-1, HHL, HL, HRY, Hairy and enhancer of split 1, Hairy homolog, Hairy-like

Gene ID: 3280

Pathways: DNA Damage Repair