IFNA1 antibody

Catalog No. ABIN1107635

The Rat Monoclonal anti-IFNA1 antibody has been validated for FACS, Func and EIA. It is suitable to detect IFNA1 in samples from Mouse.

Quick Overview for IFNA1 antibody (ABIN1107635)

Target: IFNA1 (Interferon, alpha 1 (IFNA1))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This IFNA1 antibody is un-conjugated

Application: Flow Cytometry (FACS), Functional Studies (Func), Enzyme Immunoassay (EIA)

Clone: F18

Product Details anti-IFNA1 Antibody

Specificity: This antibody recognises most isoforms of natural and recombinant alpha Interferon. It does not cross-react with Murine beta or gamma Interferon, nor with Human alpha Interferon. The antibody exhibits neutralizing activity of approximately 6.25 x 10e4 neutralizing units/mg.

Cross-Reactivity (Details): Species reactivity (tested):Mouse.

Purification: Protein G

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at -20 °C for 6 month.

Expiry Date: 6 months

Target Details for IFNA1

Target: IFNA1 (Interferon, alpha 1 (IFNA1))

Alternative Name: IFNA1 / Interferon-alpha 1

Background: The type I interferons consist of 14 different alpha isoforms (subtypes with slightly different specificities), and single beta, omega, epsilon and kappa isoforms. Homologous molecules are found in many species, including rats and mice (and most mammals), and have been identified in birds, reptiles and fish species. Interferon alpha is produced primarily by plasmacytoid dendritic cells and is a potent component of the anti viral innate immune response, it modulates adaptive immunity. The classification of mammalian cytokines with antiviral activity, is well documented as being either Type I Interferon (IFNI) or Type II Interferon (IFNII). This is not the case for avian IFNs however, even though IFN was first detected in the chicken. A growing number of functional studies indicate similarities between chicken IFN and mammalian IFNI, revealing the conservation of cysteine residues and the existence of around ten closely related intron-less IFN alpha genes. Further research has shown that chIFN-alpha genes are strongly expressed following viral infection of monocyte-derived macrophage and embryo fibroblasts and that recombinant chicken IFN acts as a potent antiviral agent.Synonyms: IFN-alpha 1, IFNA13, Interferon alpha-D, LeIF D

Gene ID: 15962

NCBI Accession: NP_034632

UniProt: P01572

Pathways: JAK-STAT Signaling, Hepatitis C