NEDD8 antibody

Catalog No. ABIN1108403

The Mouse Monoclonal anti-NEDD8 antibody is suitable to detect NEDD8 in samples from Human. It has been validated for WB, IF, IHC (p), FACS and EIA.

Quick Overview for NEDD8 antibody (ABIN1108403)

Target: NEDD8 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This NEDD8 antibody is un-conjugated

Application: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Clone: 1A7

Product Details anti-NEDD8 Antibody

Specificity: This antibody reacts to NEDD8.

Cross-Reactivity (Details): Species reactivity (tested):Human.

Purification: Purified

Isotype: IgG1

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: PBS, 0.05 % sodium azide, 0,5 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Target Details for NEDD8

Target: NEDD8 (Neural Precursor Cell Expressed, Developmentally Down-Regulated 8 (NEDD8))

Alternative Name: NEDD8

Background: Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C-APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins.Tissue specificity: Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes.Synonyms: Neural precursor cell expressed developmentally down-regulated protein 8

Molecular Weight: 9 kDa

Gene ID: 4738

Pathways: Ubiquitin Proteasome Pathway