TREM2 antibody

Catalog No. ABIN1109326

This Rat Monoclonal antibody specifically detects TREM2 in IP and EIA. It exhibits reactivity toward Mouse.

Quick Overview for TREM2 antibody (ABIN1109326)

Target: TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This TREM2 antibody is un-conjugated

Application: Immunoprecipitation (IP), Enzyme Immunoassay (EIA)

Clone: 6-00E-009

Product Details anti-TREM2 Antibody

Specificity: The monoclonal antibody 6E9 recognizes membrane-bound as well as soluble triggering receptor expressed on myeloid cells-2 (TREM-2).

Cross-Reactivity (Details): Species reactivity (tested):Mouse

Purification: Purified

Immunogen: Mouse recombinant TREM-2 protein

Isotype: IgG2b

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 02 % Sodium Azide, 0.1 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store undiluted at 2-8 °C.

Target Details for TREM2

Target: TREM2 (Triggering Receptor Expressed On Myeloid Cells 2 (TREM2))

Alternative Name: TREM2

Background: TREM-2 is a 26 kDa transmembrane glycoprotein that consists of a single extracellular immunoglobulin-like domain, a transmembrane region with a charged lysine residue and a short cytoplasmic tail. It associates with DNAX-activation protein 12 (DAP12) for signaling and function. TREM-2 is expressed on immature monocyte-derived dendritic cells. After activation by microbial products or tumor necrosis factor (TNF) and TNF-related proteins, dendritic cells downregulate the expression of TREM-2. TREM-2 is also expressed by osteoclasts and microglia, where it is involved in bone modeling and brain function, respectively. Another role of TREM-2 might be promoting the removal of apoptotic cells, organic matrix and macromolecules by microglia. Defects in TREM-2 are a cause of polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL), also called presenile dementia with bone cysts or Nasu-Hakola disease (NHD). TREM-2, like TREM-1, can be cleaved on the membrane to release a soluble form of TREM-2 (sTREM-2). Elevated levels of sTREM-2 in CSF of multiple sclerosis patients have been detected. This elevated level may inhibit the anti-inflammatory function of the membrane-bound receptor suggesting sTREM-2 to be a possible target for future therapies.Synonyms: TREM-2, Trem2a, Trem2b, Trem2c, Triggering receptor expressed on monocytes 2, Triggering receptor expressed on myeloid cells 2

Gene ID: 83433

NCBI Accession: NP_112544

UniProt: Q99NH8