Bcl-2 antibody

Catalog No. ABIN1112797

This Mouse Monoclonal antibody specifically detects Bcl-2 in WB, IHC, IHC (p) and ICC. It exhibits reactivity toward Mouse.

Quick Overview for Bcl-2 antibody (ABIN1112797)

Target: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Reactivity: Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This Bcl-2 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Clone: D24-5

Product Details anti-Bcl-2 Antibody

Immunogen: Recombinant Bcl-2 protein.

Isotype: IgG2b

Application Details

Application Notes: WB (1:10,000), IHC-P (1:200), ICC (1:500). Other applications have not been tested. The optimal dilutions should be determined by end user.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide.

Preservative: Sodium azide, Thimerosal (Merthiolate)

Storage: 4 °C/-20 °C

Storage Comment: Store at 4 °C after thawing (1 week). Aliquot and store at -20 °C for long term (at least one year). Avoid repeated freeze and thaw cycles.

Expiry Date: 12 months

Target Details for Bcl-2

Target: Bcl-2 (BCL2) (B-Cell CLL/lymphoma 2 (BCL2))

Alternative Name: B-Cell Lymphoma 2, Bcl-2

Background: Bcl-2 (B-cell lymphoma 2) is the founding member of the Bcl-2 family of apoptosis regulator proteins encoded by the BCL2 gene. 1,2 Bcl-2 is an important regulator of photoreceptor cell death in retinal degenerations. 3 The bcl-2 protooncogene, which protects various cell types from apoptotic cell death, is expressed in the developing and adult nervous system. Bcl-2 may play an important role in survival of neurons both during development and throughout adult life. 4

Pathways: MAPK Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling