IL-33 antibody

Catalog No. ABIN1169164

This Rabbit Polyclonal antibody specifically detects IL-33 in WB and ELISA. It exhibits reactivity toward Mouse.It has been mentioned in 1 publication

Quick Overview for IL-33 antibody (ABIN1169164)

Target: IL-33 (IL33) (Interleukin 33 (IL33))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This IL-33 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-IL-33 Antibody

Purpose: anti-IL-33 (mouse), pAb

Specificity: Recognizes mouse IL-33. Detects a band of ~18 kDa by Western blot. Does not cross-react with human IL-33.

No Cross-Reactivity: Human

Cross-Reactivity (Details): Does not cross-react with human IL-33.

Characteristics: Polyclonal Antibody. Recognizes mouse IL-33. Detects a band of ~18 kDa by Western blot. Does not cross-react with human IL-33. Source: Rabbit. Applications: ELISA, WB. Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30 kDa human IL33 is converted by CASP1 to a 18 kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.

Sterility: 0.2 μm filtered

Immunogen: Recombinant mouse IL-33.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.2μm-filtered solution in PBS, pH 7.4.

Preservative: Without preservative

Handling Advice: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

+4°C

-20°C

Stable for at least 6 months after receipt when stored at -20°C.

Expiry Date: 6 months

References for anti-IL-33 antibody (ABIN1169164)

Hayakawa, Hayakawa, Kume, Tominaga: "Soluble ST2 blocks interleukin-33 signaling in allergic airway inflammation." in: The Journal of biological chemistry, Vol. 282, Issue 36, pp. 26369-80, (2007) (PubMed).

Target Details for IL-33

Target: IL-33 (IL33) (Interleukin 33 (IL33))

Alternative Name: IL-33

Background:

Alternate Names/Synonyms: Interleukin-33, IL-1F11, NF-HEV

Product Description: Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30 kDa human IL33 is converted by CASP1 to a 18 kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1(MAPK3)/ERK2(MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis.

UniProt: Q8BVZ5

Pathways: Production of Molecular Mediator of Immune Response