DLL4 antibody (Extracellular Domain)

Catalog No. ABIN1169263

This Mouse Monoclonal antibody specifically detects DLL4 in WB and ELISA. It exhibits reactivity toward Human.

Quick Overview for DLL4 antibody (Extracellular Domain) (ABIN1169263)

Target: DLL4 (delta-Like 4 (DLL4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This DLL4 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Clone: DL86-3AG

Product Details anti-DLL4 Antibody

Binding Specificity: Extracellular Domain

Purpose: anti-DLL4 (human), mAb (DL86-3AG)

Specificity: Recognizes human DLL4.

Characteristics: Monoclonal Antibody. Recognizes human DLL4. Isotype: Mouse IgG1kappa. Clone: DL86-3AG. Applications: ELISA, WB. Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, pro-moting the timely formation of a well differentiated vascular network. DLL4-Notch1 signaling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.

Sterility: 0.2 μm filtered

Immunogen: Recombinant human DLL4 (extracellular domain).

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.2μm-filtered solution in PBS, pH 7.4.

Preservative: Without preservative

Handling Advice: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Expiry Date: 12 months

Target Details for DLL4

Target: DLL4 (delta-Like 4 (DLL4))

Alternative Name: DLL4

Background:

Alternate Names/Synonyms: Delta-like Protein 4, Delta4

Product Description: The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, pro-moting the timely formation of a well differentiated vascular network. DLL4-Notch1 signaling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.

UniProt: Q9NR61

Pathways: Notch Signaling