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ANGPTL4 antibody

ANGPTL4 Reactivity: Human WB, IHC, ELISA Host: Mouse Monoclonal Kairos-1 unconjugated
Catalog No. ABIN1169316
  • Target See all ANGPTL4 Antibodies
    ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))
    Reactivity
    • 55
    • 27
    • 22
    • 4
    • 4
    • 1
    Human
    Host
    • 64
    • 13
    • 2
    Mouse
    Clonality
    • 68
    • 11
    Monoclonal
    Conjugate
    • 54
    • 13
    • 6
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ANGPTL4 antibody is un-conjugated
    Application
    • 64
    • 37
    • 34
    • 9
    • 6
    • 6
    • 6
    • 5
    • 4
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), ELISA
    Specificity
    Recognizes the fibrinogen-like domain (FLD) of human ANGPTL4. Detects a band of ~62 kDa and ~35 kDa by Western blot.
    Cross-Reactivity
    Human
    Cross-Reactivity (Details)
    Does not cross-react with other ANGPTL family proteins.
    Sterility
    0.2 μm filtered
    Immunogen
    Recombinant human ANGPTL4.
    Clone
    Kairos-1
    Isotype
    IgG1
    Top Product
    Discover our top product ANGPTL4 Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    Lot specific
    Buffer
    0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives.
    Preservative
    Without preservative
    Storage
    4 °C,-20 °C
    Storage Comment
    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.
    Expiry Date
    12 months
  • Target
    ANGPTL4 (Angiopoietin-Like 4 (ANGPTL4))
    Alternative Name
    ANGPTL4 (ANGPTL4 Products)
    Synonyms
    ANGPTL2 antibody, ARP4 antibody, FIAF antibody, HFARP antibody, NL2 antibody, PGAR antibody, pp1158 antibody, Arp4 antibody, Bk89 antibody, Fiaf antibody, Hfarp antibody, Ng27 antibody, Pgar antibody, Pgarg antibody, Pp1158 antibody, ANGPTL4 antibody, fiaf antibody, im:7144703 antibody, si:rp71-39b20.7 antibody, angiopoietin like 4 antibody, angiopoietin-like 4 antibody, ANGPTL4 antibody, Angptl4 antibody, angptl4 antibody
    Background
    ANGPTL4 mainly expressed in endothelial cells (hypoxia-induced). Regulates angiogenesis and modulates tumorgenesis and directly regulates lipid, glucose, and energy metabolism. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. ANGPTL4 is a protein consisting of an N-terminal coiled-coil domain and a C-terminal fibrinogen-like domain (FLD). Both domains have distinct biological functions. The coiled-coil domain is responsible for the inhibitory effects on lipoprotein lipase (LPL) converting the active form of LPL into an inactive form, and the FLD domain mediates its antiangiogenic functions. The coiled coil and the FLD domains are separated by a short linker that can be cleaved after secretion. ANGPTL4 appears on the cell surface as the full-length form, where it can be released by heparin treatment. ANGPTL4 protein is then proteolytically cleaved by proprotein convertases (PCs), including furin, PC5/6, paired basic amino acid-cleaving enzyme 4, and PC7.
    UniProt
    Q9BY76
    Pathways
    Regulation of Lipid Metabolism by PPARalpha
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