TNFSF18 antibody

Catalog No. ABIN1169328

The Rabbit Polyclonal anti-TNFSF18 antibody (ABIN1169328) specifically detects TNFSF18 in WB, ELISA and IHC. The antibody is reactive with Human samples.

Quick Overview for TNFSF18 antibody (ABIN1169328)

Target: TNFSF18 (Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This TNFSF18 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC)

Product Details anti-TNFSF18 Antibody

Purpose: anti-GITRL (human), pAb

Specificity: Recognizes human GITRL. Detects a band of ~15-17 kDa by Western blot. Does not cross-react with mouse GITRL.

No Cross-Reactivity: Mouse (Murine)

Cross-Reactivity (Details): Does not cross-react with mouse GITRL.

Characteristics: Polyclonal Antibody. Recognizes human GITRL. Detects a band of ~15-17 kDa by Western blot. Does not cross-react with mouse GITRL. Source: Rabbit. Applications: ELISA, IHC, WB. Liquid. 0.2μm-filtered solution in PBS, pH 7.4. Contains no preservatives. GITRL is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis, .). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T-cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.

Sterility: 0.2 μm filtered

Immunogen: Recombinant human GITRL.

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: 0.2μm-filtered solution in PBS, pH 7.4.

Preservative: Without preservative

Handling Advice: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Storage: 4 °C,-20 °C

Storage Comment:

+4°C

-20°C

Stable for at least 6 months after receipt when stored at -20°C.

Expiry Date: 6 months

Target Details for TNFSF18

Target: TNFSF18 (Tumor Necrosis Factor (Ligand) Superfamily, Member 18 (TNFSF18))

Alternative Name: GITRL

Background:

Alternate Names/Synonyms: Glucocorticoid-induced TNF Receptor Ligand, AITRL, Activation-inducible TNF-related Ligand, TNFSF18

Product Description: GITRL is expressed on dendritic cells (DC), monocytes, macrophages, B cells, activated T cells, endothelial cells, osteoclasts and various healthy non-lymphoid tissues (e.g. testis, ..). GITRL is constitutively expressed and released as soluble form by solid tumors and various hematopoietic malignancies. GITRL causes differentiation of osteoclasts, activation of macrophages, but also alteration of carcinoma and leukemia cells and influences apoptosis. Binding to GITR is important in regulating T-cell proliferation and TCR-mediated apoptosis. GITRL is implicated in development of autoimmune diseases and in the immune response against infectious pathogens and tumors.

UniProt: Q9UNG2