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IFIH1 antibody (AA 78-555)

The Mouse Monoclonal anti-IFIH1 antibody has been validated for WB, ELISA and IP. It is suitable to detect IFIH1 in samples from Human.
Catalog No. ABIN1169453

Quick Overview for IFIH1 antibody (AA 78-555) (ABIN1169453)

Target

See all IFIH1 Antibodies
IFIH1 (Interferon Induced with Helicase C Domain 1 (IFIH1))

Reactivity

  • 44
  • 14
  • 4
  • 2
  • 2
  • 2
  • 1
Human

Host

  • 38
  • 7
  • 2
Mouse

Clonality

  • 37
  • 10
Monoclonal

Conjugate

  • 41
  • 3
  • 2
  • 1
This IFIH1 antibody is un-conjugated

Application

  • 37
  • 24
  • 21
  • 12
  • 8
  • 7
  • 6
  • 2
  • 2
  • 1
  • 1
Western Blotting (WB), ELISA, Immunoprecipitation (IP)

Clone

Hely-1
  • Binding Specificity

    • 6
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 78-555

    Specificity

    Recognizes human MDA5.

    Cross-Reactivity

    Human

    Purification

    Purified from concentrated hybridoma tissue culture supernatant.

    Purity

    >95 % (SDS-PAGE)

    Immunogen

    Recombinant human MDA5 (aa 78-555).

    Isotype

    IgG1
  • Application Notes

    Optimal working dilution should be determined by the investigator.

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    Lot specific

    Buffer

    In PBS containing 10 % glycerol and 0.02 % sodium azide.

    Preservative

    Sodium azide

    Precaution of Use

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Storage

    4 °C,-20 °C

    Storage Comment

    Short Term Storage: +4°C
    Long Term Storage: -20°C
    Stable for at least 1 year after receipt when stored at -20°C.

    Expiry Date

    12 months
  • Target

    IFIH1 (Interferon Induced with Helicase C Domain 1 (IFIH1))

    Alternative Name

    MDA5

    Background

    RIG-I and MDA5 are highly conserved helicases involved in the innate immune response to virus. RIG-I is a member of the DEAD-box RNA helicases and is activated by cytoplasmic dsRNA and 5'-ppp RNA produced during the viral replication. The protein is characterized by a N-terminal region with two caspase recruitment domains (CARD) and a C-terminal region harboring potential ATP-dependent RNA helicase activity. RIG-1 recruits the CARD adaptor inducing IFN-beta (Cardif) in a CARD-CARD-dependent manner resulting in NF-kappaB and IRF3 activation.

    UniProt

    Q9BYX4

    Pathways

    Activation of Innate immune Response
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