CD14 antibody

Catalog No. ABIN1177335

Cited in 1 publication. The Mouse Monoclonal anti-CD14 antibody (Clone M5E2) (ABIN1177335) specifically detects CD14 in FACS and Neut. The antibody is reactive with Human, Cynomolgus, Rhesus Monkey, Baboon and Dog samples.

Quick Overview for CD14 antibody (ABIN1177335)

Target: CD14

Reactivity: Human, Cynomolgus, Rhesus Monkey, Baboon, Dog

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD14 antibody is un-conjugated

Application: Flow Cytometry (FACS), Neutralization (Neut)

Clone: M5E2

Product Details anti-CD14 Antibody

Purification: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Sterility: 0.2 μm filtered

Endotoxin Level: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Isotype: IgG2a kappa

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Preservative: Azide free

Storage: 4 °C

Storage Comment: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

References for anti-CD14 antibody (ABIN1177335)

Wright, Ramos, Tobias, Ulevitch, Mathison: "CD14, a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein." in: Science (New York, N.Y.), Vol. 249, Issue 4975, pp. 1431-3, (1990) (PubMed).

Target Details for CD14

Target: CD14

Alternative Name: CD14

Background: The M5E2 monoclonal antibody specifically binds to CD14, a 53-55 kDa glycosylphosphatidylinositol (GPI)-anchored single chain glycoprotein expressed at high levels on monocytes. Additionally, the anti-CD14 antibody reacts with interfollicular macrophages, reticular dendritic cells, and some Langerhans cells. CD14 has been identified as a high affinity cell-surface receptor for complexes of lipopolysaccharide (LPS) and serum LPS-binding protein, LPB.
Synonyms: LPS receptor, LPS-R, Myeloid cell-specific leucine-rich glycoprotein

Pathways: TLR Signaling, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Toll-Like Receptors Cascades