NCR1 antibody (Natural Cytotoxicity Triggering Receptor 1)

Details for Product anti-NCR1 Antibody No. ABIN1177346
Antigen
  • CD335
  • LY94
  • NK-p46
  • NKP46
  • Ly94
  • NKp46
  • KILR-1
  • Nk-p46
  • Nkp46
  • natural cytotoxicity triggering receptor 1
  • NCR1
  • Ncr1
Alternatives
anti-Cow (Bovine) NCR1 antibody for Flow Cytometry
Reactivity
Human
109
60
24
14
4
3
Host
Mouse
82
46
24
Clonality (Clone)
Monoclonal ()
Conjugate
This NCR1 antibody is un-conjugated
16
11
8
6
3
3
3
3
3
3
2
1
1
1
1
1
1
Application
Functional Studies (Func), Flow Cytometry (FACS)
70
64
31
17
15
13
7
6
6
5
5
2
1
Options
Brand BD Pharmingen™
Clone 9E2-NKp46
Isotype IgG1, kappa
Purification The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Sterility 0.2 μm filtered
Endotoxin Level Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
Plasmids, Primers & others Plasmids, Primers & others NCR1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Alternative Name NKp46 (NCR1 Antibody Abstract)
Background NKp46, a major cytoxicity receptor of NK cells, is a type I membrane glycoprotein (46 kDa) is expressed on resting and activated NK cells. Its extracellular region contains two C2-type, Ig-like domains. The transmembrane domain contains a positively charged amino acid (Arg) which could be involved in stabilizing the association with CD3zeta. Its intracellular region does not contain immunoreceptor tyrosine-based activating motifs (ITAM), but it is linked to intracytoplasmic transduction machinery by its association with CD3zeta and FcepsilonRIgamma adaptor proteins. NKp46 along with NKp30 and NKp44 are referred to as natural cytoxicity receptors (NCR) and play a very important role in killing virus-infected, tumor cells and MHC-class I-unprotected cells. This antibody is routinely tested by flow cytometric analysis.
Pathways Regulation of Leukocyte Mediated Immunity
Application Notes This NA/LE™ format is useful for in vitro functional studies.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
Preservative Azide free
Storage 4 °C
Storage Comment Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
Supplier Images
Flow Cytometry (FACS) image for anti-Natural Cytotoxicity Triggering Receptor 1 (NCR1) antibody (ABIN1177346) anti-Natural Cytotoxicity Triggering Receptor 1 (NCR1) antibody
Product cited in: Mandelboim, Porgador: "NKp46." in: The international journal of biochemistry & cell biology, Vol. 33, Issue 12, pp. 1147-50, 2001 (PubMed).

Sivori, Pende, Bottino, Marcenaro, Pessino, Biassoni, Moretta, Moretta et al.: "NKp46 is the major triggering receptor involved in the natural cytotoxicity of fresh or cultured human NK cells. Correlation between surface density of NKp46 and natural cytotoxicity against ..." in: European journal of immunology, Vol. 29, Issue 5, pp. 1656-66, 1999 (PubMed).

Sivori, Vitale, Morelli, Sanseverino, Augugliaro, Bottino, Moretta, Moretta: "p46, a novel natural killer cell-specific surface molecule that mediates cell activation." in: The Journal of experimental medicine, Vol. 186, Issue 7, pp. 1129-36, 1997 (PubMed).

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