ERBB3 antibody

Catalog No. ABIN119014

This Mouse Monoclonal antibody specifically detects ERBB3 in IP, FACS, IHC (fro) and EIA. It exhibits reactivity toward Human.

Quick Overview for ERBB3 antibody (ABIN119014)

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This ERBB3 antibody is un-conjugated

Application: Immunoprecipitation (IP), Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Clone: SGP-1

Product Details anti-ERBB3 Antibody

Specificity: This antibody recognises an extra cellular domain of the ErbB3 protein.

Purification: Protein A chromatography

Immunogen: Wheat germ lectin purified ErbB3 protein

Isotype: IgG1

Application Details

Application Notes: Flow cytometry. Immunohistochemistry on frozen sections (5-10 μg/mL no special pretreatment required). Immunoprecipitation. ELISA. Not suitable for paraffin sections and western blotting.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: PBS, pH 7.4, with 0.09 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C to -70 °C for longer.

Target Details for ERBB3

Target: ERBB3 (Receptor Tyrosine-Protein Kinase ErbB-3 (ERBB3))

Alternative Name: ERBB3 / HER3

Background: ErbB3 is a 180 kD glycoprotein which is a growth factor receptor with tyrosine kinase activity. ErbB3 is expressed widely in normal human tissues, but is overexpressed in some tumours, including those of the breast, stomach, pancreas and colon.Synonyms: ERBB-3, HER-3, Proto-oncogene-like protein c-ErbB-3, Receptor tyrosine-protein kinase erbB-3, Tyrosine kinase-type cell surface receptor HER3, c-erbB-3

Gene ID: 2065

NCBI Accession: NP_001005915

UniProt: P21860

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway