CD46 antibody

Catalog No. ABIN119581

This Mouse Monoclonal antibody specifically detects CD46 in WB, FACS and IP. It exhibits reactivity toward Human and Cow.

Quick Overview for CD46 antibody (ABIN119581)

Target: CD46

Reactivity: Human, Cow

Host: Mouse

Clonality: Monoclonal

Conjugate: This CD46 antibody is un-conjugated

Application: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP)

Clone: MEM-258

Product Details anti-CD46 Antibody

Cross-Reactivity (Details): Species reactivity (tested):Human, Bovine.

Purification: Affinity Chromatography on Protein A

Immunogen: HPB-ALL human T cell line

Isotype: IgG1

Application Details

Application Notes: Western blotting (non-reducing conditions). Immunoprecipitation. Flow cytometry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 1.0 mg/mL

Buffer: Tris buffered saline (TBS) pH ~8.0, 15 mM Sodium Azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: 4 °C/-20 °C

Storage Comment: Store the original vial at 2-8 °C. Freeze stock solution or aliquots thereof at -20 °C.

Target Details for CD46

Target: CD46

Alternative Name: CD46 / MCP

Background: CD46 (MCP, membrane cofactor protein) is a multifunctional cell surface transmembrane protein that binds and inactivates C3b and C4b complement fragments, regulates T cell-induced inflammatory responses by either inhibiting (CD46-1 isoform) or increasing (CD46-2 isoform) the contact hypersensitivity reaction. CD46 also serves as a receptor for several human pathogens (both bacteria and viruses), and its ligation alteres T lymphocyte polarization toward antigen-presenting cells or target cells, inhibiting lymphocyte function. CD46 is a protector of placental tissue and is also expressed on the inner acrosomal membrane of spermatozoa.Synonyms: MIC10, Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen

Gene ID: 9606

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization