Integrin Alpha2b antibody (FITC)

Catalog No. ABIN119841

This anti-Integrin Alpha2b antibody is a Rat Monoclonal antibody detecting Integrin Alpha2b in FACS. Suitable for Mouse. This Primary Antibody has been cited in 2+ publications.

Quick Overview for Integrin Alpha2b antibody (FITC) (ABIN119841)

Target: Integrin Alpha2b (CD41)

Reactivity: Mouse

Host: Rat

Clonality: Monoclonal

Conjugate: This Integrin Alpha2b antibody is conjugated to FITC

Application: Flow Cytometry (FACS)

Clone: MWReg30

Product Details anti-Integrin Alpha2b Antibody (FITC)

Specificity: This antibody recognises the integrin alpha IIb subunit CD41.

Purification: Protein G affinity chromatography

Isotype: IgG1

Application Details

Application Notes: Flow cytometry: use 10 μL of neat - 1/10 diluted antibody to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: Clone MWReg30 has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo . We recommend the use of ABIN119839 for use in functional studies.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, pH 7.4, containing 0.09 % sodium azide and 1 % BSA

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing. This product is photosensitive and should be protected from light.

Storage: 4 °C/-20 °C

Storage Comment: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

References for anti-Integrin Alpha2b antibody (FITC) (ABIN119841)

Zanzinger, Schellack, Nausch, Cerwenka: "Regulation of triggering receptor expressed on myeloid cells 1 expression on mouse inflammatory monocytes." in: Immunology, Vol. 128, Issue 2, pp. 185-95, (2009) (PubMed).

Larson, Watson: "Regulation of proplatelet formation and platelet release by integrin alpha IIb beta3." in: Blood, Vol. 108, Issue 5, pp. 1509-14, (2006) (PubMed).

Target Details for Integrin Alpha2b

Target: Integrin Alpha2b (CD41)

Alternative Name: CD41 / ITGA2B

Background: CD41 is expressed on platelets and megakaryocytes and forms a heterodimer with CD61. CD41/CD61 is important for platelet adhesion and aggregation.Synonyms: GP2B, GPalpha IIb, ITGAB, Integrin alpha-IIb, Platelet membrane glycoprotein IIb

Gene ID: 16399

NCBI Accession: NP_034705

UniProt: Q9QUM0

Pathways: Integrin Complex