RGS3 antibody (AA 401-519)

Catalog No. ABIN127074

The Rabbit Polyclonal anti-RGS3 antibody (ABIN127074) specifically detects RGS3 in WB and IP. The antibody is reactive with Human samples.

Quick Overview for RGS3 antibody (AA 401-519) (ABIN127074)

Target: RGS3 (Regulator of G-Protein Signaling 3 (RGS3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This RGS3 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP)

Product Details anti-RGS3 Antibody

Binding Specificity: AA 401-519

Specificity: This antibody detects human RGS3. Other species not tested.

Purification: Protein A chromatography

Immunogen: E. coli-expressed human RGS3 (aa 401-519)

Application Details

Application Notes: Western Blot: 1.0 μg/mL. Immunoprecipitation.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Restrictions: For Research Use only

Handling

Concentration: 0.2 mg/mL

Buffer: PBS, pH 7.2, containing 50 % glycerol, 1 % BSA, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Avoid repeated freezing and thawing.

Storage: -20 °C

Storage Comment: Store the antibody undiluted (in aliquots) at -20 °C to -70 °C.

Target Details for RGS3

Target: RGS3 (Regulator of G-Protein Signaling 3 (RGS3))

Alternative Name: RGS3

Background: RGS3 (regulator of G protein signaling 3) is a 519-residue protein that is widely expressed in many tissues and cells. The protein contains an RGS domain near the carboxy terminus that serves as a GTPase-activating protein (GAP). RGS3 negatively regulates the activation of Giα and Gαq. A truncated RGS3 (RGS3T), with its N-terminal 313 residues removed, has been shown to negatively regulate acenylyl cyclase and PLC. RGS3T may be localized in the nucleus and RGS3 is found in cytoplasm. Translocation to membrane is important for the RGS proteins to interact with heterotrimeric G proteins.Synonyms: RGP3, Regulator of G-protein signaling 3

Gene ID: 5998

NCBI Accession: NP_060260

UniProt: P49796

Pathways: Myometrial Relaxation and Contraction, Regulation of G-Protein Coupled Receptor Protein Signaling