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HDAC4 antibody
HDAC4
Reactivity: Human, Mouse, Rat
WB
Host: Rabbit
Polyclonal
unconjugated
Product Details anti-HDAC4 Antibody
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Target
See all HDAC4 Antibodies
HDAC4
(Histone Deacetylase 4 (HDAC4))
Reactivity
All reactivities for HDAC4 antibodies
Human, Mouse, Rat
Host
All hosts for HDAC4 antibodies
Rabbit
Clonality
All clonalities for HDAC4 antibodies
Polyclonal
Conjugate
All conjugates for HDAC4 antibodies
This HDAC4 antibody is un-conjugated
Application
All applications for HDAC4 antibodies
Western Blotting (WB)
Specificity
The antibody detects ~140 kDa HDAC-4. It does not cross-react with other HDAC proteins including HDAC1, 2, 3, 5, 6, 7, and 8.
Purification
Affinity purified
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Discover our top product HDAC4 Primary Antibody
Alternatives
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Application Details
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Application Notes
Western Blot: 1 μg/mL. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Restrictions
For Research Use only
Handling
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Concentration
0.5 mg/mL
Buffer
PBS containing 50 % glycerol, 1.0 % BSA, and 0.02 % sodium azide
Preservative
Sodium azide
Precaution of Use
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice
Avoid repeated freezing and thawing.
Storage
-20 °C/-80 °C
Storage Comment
Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C.
Target Details for HDAC4
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Target
HDAC4
(Histone Deacetylase 4 (HDAC4))
Alternative Name
HDAC4 (HDAC4 Products )
Synonyms
CG1770 antibody, DHDAC4 antibody, Dmel\\CG1770 antibody, GC1770 antibody, HDAC antibody, HDAC4a antibody, dHDAC4 antibody, dmHDA405 antibody, hdac4 antibody, dana_GLEANR_19966 antibody, DanaGF18710 antibody, GF18710 antibody, HDAC4 antibody, AHO3 antibody, BDMR antibody, HA6116 antibody, HD4 antibody, HDAC-4 antibody, HDAC-A antibody, HDACA antibody, 4932408F19Rik antibody, AI047285 antibody, wu:fa96d08 antibody, wu:fc56f08 antibody, zgc:152701 antibody, histone deacetylase 4 antibody, hypothetical protein antibody, Histone deacetylase 4 antibody, GF18710 gene product from transcript GF18710-RC antibody, PTRG_03699 antibody, PGTG_15512 antibody, HDAC4 antibody, Dana\GF18710 antibody, Hdac4 antibody, hdac4 antibody
Background
HDAC4 is a member of the class II mammalian histone deacetylases, which consists of 1084 amino acid residues. Its C-terminal sequence is highly similar to the deacetylase domain of yeast HDA1. HDAC4, unlike other deacetylases, shuttles between the nucleus and cytoplasm in a process involving active nuclear export. Association of HDAC4 with 14-3-3 results in sequestration of HDAC 4 protein in the cytoplasm. In the nucleus, HDAC4 associates with the myocyte enhancer factor MEF2A. Binding of HDAC4 to MEF2A results in the repression of MEF2A transcriptional activation. HDAC4 has also been shown to interact with other deacetylases such as HDAC3 as well as the corepressors NcoR and SMART.Synonyms: HD4, Histone deacetylase 4, KIAA0288
Gene ID
9759
NCBI Accession
NP_006028
UniProt
P56524
Pathways
Regulation of Muscle Cell Differentiation , Skeletal Muscle Fiber Development , Regulation of Carbohydrate Metabolic Process
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