FGFR4 antibody

Catalog No. ABIN1302415

This anti-FGFR4 antibody is a Mouse Monoclonal antibody detecting FGFR4 in FACS and ICC. Suitable for Human.

Quick Overview for FGFR4 antibody (ABIN1302415)

Target: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This FGFR4 antibody is un-conjugated

Application: Flow Cytometry (FACS), Immunocytochemistry (ICC)

Clone: 4FR6D3

Product Details anti-FGFR4 Antibody

Purpose: Anti-Hu CD334 Purified

Specificity: The mouse monoclonal antibody 4FR6D3 reacts with an extracellular epitope of CD334, the fibroblast growth factor receptor 4, which is an approximately 88 kDa receptor tyrosine kinase expressed in variety of tissues.

Cross-Reactivity (Details): Human

Purification: Purified by protein-A affinity chromatography.

Purity: > 95 % (by SDS-PAGE)

Immunogen: NIH 3T3 cells transfected with full length human CD334

Isotype: IgG1 kappa

Application Details

Application Notes: Flow cytometry: Recommended dilution: 2-6 μg/mL.

Restrictions: For Research Use only

Handling

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for FGFR4

Target: FGFR4 (Fibroblast Growth Factor Receptor 4 (FGFR4))

Alternative Name: CD334

Background: Fibroblast growth factor receptor 4,CD334 / FGFR4 (fibroblast growth factor receptor 4), a transmembrane tyrosine kinase, which is expressed in many tissues, such as in lung, kidney, muscle, heart, pancreas, intestine and other, acts as a receptor for several fibroblast growth factors, namely FGF1, FGF2, FGF6, FGF8, and FGF19. Interaction with these growth factors initiates in cell the signaling cascades leading to the mitogenesis and cell differentiation. Presence of CD334 Gly338Arg allele correlates with prognostic parameters in various cancer studies. CD334 plays multiple roles in the organism, including those of muscle regeneration, cholesterol-to-bile acid metabolism, or glucose homeostasis.,FGFR4, TKF, JTK2, FGFR-4

Gene ID: 2264

UniProt: P22455

Pathways: RTK Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Neurotrophin Signaling Pathway, Carbohydrate Homeostasis, Growth Factor Binding