CCDC98 antibody (N-Term)

Catalog No. ABIN1302443

The Mouse Monoclonal anti-CCDC98 antibody is suitable to detect CCDC98 in samples from Human. It has been validated for WB, IP and ICFC.

Quick Overview for CCDC98 antibody (N-Term) (ABIN1302443)

Target: CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))

Reactivity: Human

Host: Mouse

Clonality: Monoclonal

Conjugate: This CCDC98 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Intracellular Flow Cytometry (ICFC)

Clone: ABRA1-01

Product Details anti-CCDC98 Antibody

Binding Specificity: AA 1-313, N-Term

Purpose: Anti-ABRA1 Purified

Cross-Reactivity (Details): Human, Other not tested

Characteristics: The mouse monoclonal antibody ABRA1-01 recognizes human ABRA1 (Abraxas, CCDC98), an adaptor protein involved in DNA repair, which migrates as a 45 kDa band on PAAGE under reducing conditions.

Purification: Purified by protein-A affinity chromatography.

Purity: > 95 % (by SDS-PAGE)

Immunogen: Recombinant protein corresponding to amino acids 1-313 of ABRA1 with N-terminal His6 tag

Isotype: IgG2a, kappa

Application Details

Application Notes: Flow cytometry: Recommended dilution: 1-2 μg/mL. Intracellular staining.
Western blotting: Reducing conditions.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do not freeze

Storage: 4 °C

Storage Comment: Store at 2-8°C. Do not freeze.

Target Details for CCDC98

Target: CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))

Alternative Name: ABRA1

Background: Abraxas 1, BRCA1 A complex subunit,ABRA1 (Abraxas), also known as CCDC98, is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation.,ABRA1, Abraxas 1, CCDC98, FAM175A

Gene ID: 84142

UniProt: Q6UWZ7

Pathways: DNA Damage Repair, Positive Regulation of Response to DNA Damage Stimulus