Caspase 1 antibody

Catalog No. ABIN1305223

This antibody specifically detects Caspase 1 in ELISA. It exhibits reactivity toward Mouse.

Quick Overview for Caspase 1 antibody (ABIN1305223)

Target: Caspase 1 (CASP1)

Reactivity: Mouse

Host: Please inquire

Conjugate: This Caspase 1 antibody is un-conjugated

Application: ELISA

Product Details anti-Caspase 1 Antibody

Detection Range: 0.15ng/mL – 10ng/mL

Minimum Detection Limit: 100pg/ml

Specificity: Detects mouse Caspase-1 (p10 and p20 domain). Does not detect human Caspase-1.

Application Details

Restrictions: For Research Use only

Handling

Concentration: Lot specific

Storage: -20 °C

Target Details for Caspase 1

Target: Caspase 1 (CASP1)

Alternative Name: Caspase-1

Background: Caspase-1 is the best-described inflammatory caspase. It processes the cytokines interleukin-1beta (IL-1beta) and interleukin-18 (IL-18) and induces pyroptotic cell death. Caspase-1 is activated by multiprotein complexes called inflammasomes in response to numerous stimuli that are detected through distinct inflammasomes. NLRC4 responds to cytosolic flagellin, murine NLRP1b responds to anthrax lethal toxin, AIM2 responds to cytosolic DNA and NLRP3/NALP3 responds to a variety of agonists including crystals._x000D_The Caspase-1 (mouse) Matched Pair Detection Set contains all reagents for the development of a sandwich ELISA to measure Caspase-1 (mouse) in cell culture supernatants. This Matched Pair Detection Set is a quantitative alternative to Western blotting to measure inflammasome activation leading to Caspase-1 cleavage and secretion.

Pathways: Apoptosis, Interferon-gamma Pathway, Positive Regulation of Endopeptidase Activity, Inflammasome