PKM2 antibody (pSer37)

Catalog No. ABIN1355883

This anti-PKM2 antibody is a Rabbit Polyclonal antibody detecting PKM2 in WB. Suitable for Human. This Primary Antibody has been cited in 1 publication.

Quick Overview for PKM2 antibody (pSer37) (ABIN1355883)

Target: PKM2 (Pyruvate Kinase M2 (PKM2))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PKM2 antibody is un-conjugated

Application: Western Blotting (WB)

Product Details anti-PKM2 Antibody

Binding Specificity: pSer37

Specificity: The antibody detects endogenous level of PKM2 only

Immunogen: Peptide sequence around phosphorylation site of pSer37 (I-D-S (p) -P-P) derived from Human PKM2.

Application Details

Application Notes: Western Blot: 1:500-1000  

Restrictions: For Research Use only

Handling

Format: Liquid

Storage: 4 °C/-20 °C

References for anti-PKM2 antibody (ABIN1355883)

Yang, Zheng, Xia, Ji, Chen, Guo, Lyssiotis, Aldape, Cantley, Lu: "ERK1/2-dependent phosphorylation and nuclear translocation of PKM2 promotes the Warburg effect." in: Nature cell biology, Vol. 14, Issue 12, pp. 1295-304, (2012) (PubMed).

Target Details for PKM2

Target: PKM2 (Pyruvate Kinase M2 (PKM2))

Alternative Name: PKM2

Background: Glycolytic enzyme that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate (PEP) to ADP, generating ATP. Stimulates POU5F1-mediated transcriptional activation. Plays a general role in caspase independent cell death of tumor cells. The ratio betwween the highly active tetrameric form and nearly inactive dimeric form determines whether glucose carbons are channeled to biosynthetic processes or used for glycolytic ATP production. The transition between the 2 forms contributes to the control of glycolysis and is important for tumor cell proliferation and survival.

Molecular Weight: 60 kDa

Pathways: Warburg Effect