IL-6 antibody

Catalog No. ABIN1383946

This Mouse Monoclonal antibody specifically detects IL-6 in WB, IHC and FACS. It exhibits reactivity toward Human and Mouse and has been mentioned in 5+ publications.

Quick Overview for IL-6 antibody (ABIN1383946)

Target: IL-6 (IL6) (Interleukin 6 (IL6))

Reactivity: Human, Mouse

Host: Mouse

Clonality: Monoclonal

Conjugate: This IL-6 antibody is un-conjugated

Application: Western Blotting (WB), Immunohistochemistry (IHC), Flow Cytometry (FACS)

Clone: B-F6

Product Details anti-IL-6 Antibody

Specificity: Recognises both natural and recombinant human IL-6

Purification: Ion exchange chromatography

Sterility: 0.22 μm filtered

Immunogen: Recombinant human IL-6,Myeloma X63/AG.8653 x Balb/c spleen cells

Isotype: IgG1 kappa

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Phosphate-buffered saline. Sterile-filtered through 0.22 μm. Carrier and preservative free

Preservative: Without preservative

Storage: 4 °C

Storage Comment: Stable at +2-8°C for 12 months. For longer storage freeze aliquots.

References for anti-IL-6 antibody (ABIN1383946)

Kube, Holtick, Vockerodt, Ahmadi, Haier, Behrmann, Heinrich, Diehl, Tesch: "STAT3 is constitutively activated in Hodgkin cell lines." in: Blood, Vol. 98, Issue 3, pp. 762-70, (2001) (PubMed).

Voorzanger, Touitou, Garcia, Delecluse, Rousset, Joab, Favrot, Blay: "Interleukin (IL)-10 and IL-6 are produced in vivo by non-Hodgkin's lymphoma cells and act as cooperative growth factors." in: Cancer research, Vol. 56, Issue 23, pp. 5499-505, (1997) (PubMed).

Wijdenes, Heinrich, Müller-Newen, Roche, Gu, Clément, Klein: "Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodies." in: European journal of immunology, Vol. 25, Issue 12, pp. 3474-81, (1996) (PubMed).

Zunino, Singh, Bass, Picker: "Immunodetection of histone epitopes correlates with early stages of apoptosis in activated human peripheral T lymphocytes." in: The American journal of pathology, Vol. 149, Issue 2, pp. 653-63, (1996) (PubMed).

Wijdenes, Clement, Klein, Morel-Fourrier, Vita, Ferrara, Peters: "Human recombinant dimeric IL-6 binds to its receptor as detected by anti-IL-6 monoclonal antibodies." in: Molecular immunology, Vol. 28, Issue 11, pp. 1183-92, (1992) (PubMed).

Target Details for IL-6

Target: IL-6 (IL6) (Interleukin 6 (IL6))

Alternative Name: IL-6

Pathways: TLR Signaling, Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagy, Cell RedoxHomeostasis, Cancer Immune Checkpoints, Inflammasome