CCRN4L antibody (AA 231-330)

Catalog No. ABIN1385748

This anti-CCRN4L antibody is a Rabbit Polyclonal antibody detecting CCRN4L in WB and ELISA. Suitable for Rat and Mouse.

Quick Overview for CCRN4L antibody (AA 231-330) (ABIN1385748)

Target: CCRN4L (CCR4 Carbon Catabolite Repression 4-Like (CCRN4L))

Reactivity: Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CCRN4L antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Product Details anti-CCRN4L Antibody

Binding Specificity: AA 231-330

Cross-Reactivity: Mouse, Rat

Predicted Reactivity: Human

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Nocturnin

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

Target Details for CCRN4L

Target: CCRN4L (CCR4 Carbon Catabolite Repression 4-Like (CCRN4L))

Alternative Name: Nocturnin

Background:

Synonyms: CCR4 carbon catabolite repression 4 like S. cerevisiae, CCR4 protein homolog, CCRN4L, NOC, NOCT_HUMAN.

Background: Nocturnin is a 431 amino acid circadian deadenylase protein that is expressed in a broad range of tissues with greatest abundance in the liver, kidney and testis. Nocturnin plays a role in circadian regulation as well as diet-induced obesity. The mRNA abundance of Nocturnin exhibits circadian rhythmicity, peaking after dusk in photoreceptors, spleen, heart, kidney and liver. Nocturnin is thought to be responisble for turning off genes that are involved in circadian regulation. In Xenopus retinal photoreceptor cells, the rhythmic regulation of Nocturnin is thought to be controlled by phosphorylated CREB. Mice lacking Nocturnin remain lean on high fat diets with a reduction in visceral fat, which suggests that this protein may also be responsible for lipid metabolism and fat storage.

Gene ID: 25819

Pathways: Ribonucleoprotein Complex Subunit Organization