ATM antibody (pTyr170)

Catalog No. ABIN1386564

This anti-ATM antibody is a Rabbit Polyclonal antibody detecting ATM in IHC (p) and IF (p). Suitable for Human, Mouse and Rat.

Quick Overview for ATM antibody (pTyr170) (ABIN1386564)

Target: ATM (Ataxia Telangiectasia Mutated (ATM))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ATM antibody is un-conjugated

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-ATM Antibody

Binding Specificity: pTyr170

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human ATM around the phosphorylation site of Tyr170 [SV(p-Y)FR]

Isotype: IgG

Application Details

Application Notes: IHC-P (1:100-500),IF (p) (1:100-500)

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C for 12 months.

Expiry Date: 12 months

Target Details for ATM

Target: ATM (Ataxia Telangiectasia Mutated (ATM))

Alternative Name: ATM

Background:

Synonyms: ATM Tyr170, ATM Y170, p-ATM Tyr170, p-ATM Y170, A-T mutated, A-T mutated homolog, AT complementation group A, AT complementation group C, AT complementation group D, AT complementation group E, AT mutated, AT protein, AT1, ATA, Ataxia telangiectasia gene mutated in human beings, Ataxia telangiectasia mutated, Ataxia telangiectasia mutated gene, Ataxia telangiectasia mutated homolog human, Ataxia telangiectasia mutated homolog, ATC, ATD, ATDC, ATE, ATM, ATM_HUMAN, DKFZp781A0353, Human phosphatidylinositol 3 kinase homolog, MGC74674, Serine protein kinase ATM, Serine-protein kinase ATM, Serine/threonine-protein kinase ATM, T cell prolymphocytic leukemia, Tefu, TEL1, TEL1, telomere maintenance 1, homolog, TELO1, Telomere fusion protein, TPLL.

Background: ATM is a 370 kDa nuclear phosphoprotein involved in the autosomal recessive disease Ataxia Telangiectasia (AT). ATM belongs to a novel family of proteins associated with cell cycle regulation, apoptosis, and response to DNA damage repair (DNA damage caused by such things as ionizing irradiation activates ATM kinase). The C terminal region has extensive homology to the catalytic domains of Phosphatidylinositol 3 kinases (PI3 kinases).

Molecular Weight: 370kDa

Pathways: p53 Signaling, Apoptosis, DNA Damage Repair, Inositol Metabolic Process, Positive Regulation of Response to DNA Damage Stimulus