SLC51B antibody (AA 1-35)

Catalog No. ABIN1386750

This anti-SLC51B antibody is a Rabbit Polyclonal antibody detecting SLC51B in ELISA, WB and IHC (p). Suitable for Mouse. This Primary Antibody has been cited in 1 publication.

Quick Overview for SLC51B antibody (AA 1-35) (ABIN1386750)

Target: SLC51B (OSTBETA) (Organic Solute Transporter beta (OSTBETA))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SLC51B antibody is un-conjugated

Application: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SLC51B Antibody

Binding Specificity: AA 1-35

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human OST-beta

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: 4 °C,-20 °C

Storage Comment: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Expiry Date: 12 months

References for anti-SLC51B antibody (ABIN1386750)

Stipanuk, Jurkowska, Niewiadomski, Mazor, Roman, Hirschberger: "Identification of Taurine-Responsive Genes in Murine Liver Using the Cdo1-Null Mouse Model." in: Advances in experimental medicine and biology, Vol. 975, pp. 475-495, (2017) (PubMed).

Target Details for SLC51B

Target: SLC51B (OSTBETA) (Organic Solute Transporter beta (OSTBETA))

Alternative Name: OST-beta

Background:

Synonyms: organic solute transporter beta Ostbeta, Organic solute transporter subunit beta, Ostbeta, Ost beta, OST-beta, OSTB, OSTB_HUMAN.

Background: The heteromeric transporter OST Alpha/OST Beta facilitates the transport of bile and other steroid solutes across the basolateral epithelial cell membrane of intestine, liver, testis, kidney and adrenal gland. OST Alpha/OST Beta expression is induced by bile acids through ligand-dependent transactivation of their genes by FXR (Farnesoid X-activated receptor). This genetic regulation suggests that in response to changes in intracellular bile acid levels, bile acids adjust the rate of their own efflux from enterocytes. OST Beta is a 128 amino acid single-pass transmembrane protein that requires OST Alpha to localize to the plasma membrane. Coexpression of OST Alpha and OST Beta is also required to convert the OST Alpha subunit to a mature glycosylated endoglycosidase H-resistant form, suggesting that co-expression facilitates trafficking of OST Alpha through the golgi apparatus. Though widely expressed, OST Beta is present at highest levels in ileum.

Gene ID: 123264

Pathways: Regulation of Carbohydrate Metabolic Process