KCNJ10 antibody (Biotin)

Catalog No. ABIN1396080

The Biotin-conjugated Rabbit Polyclonal anti-KCNJ10 antibody (ABIN1396080) specifically detects KCNJ10 in WB and IHC (p). The antibody is reactive with Human, Rat and Mouse samples.

Quick Overview for KCNJ10 antibody (Biotin) (ABIN1396080)

Target: KCNJ10 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 10 (KCNJ10))

Reactivity: Human, Rat, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This KCNJ10 antibody is conjugated to Biotin

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-KCNJ10 Antibody (Biotin)

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Kir4.1

Isotype: IgG

Application Details

Application Notes: WB: (1:100-1000), IHC-P: (1:100-500)
Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 100 μg/mL BSA, 50 % glycerol and 0.09 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at 4 °C for 12 months.

Expiry Date: 12 months

Target Details for KCNJ10

Target: KCNJ10 (Potassium Inwardly-Rectifying Channel, Subfamily J, Member 10 (KCNJ10))

Alternative Name: Kir4.1

Background: The KIR (for inwardly rectifying potassium channel) family of potassium channels possess a greater tendency to allow potassium to flow into the cell rather than out of it. KIR4.1, also known as Kir1.2, is highly expressed in brain including glial cells, astrocytes and cortical neurons. KIR4.1 is also expressed in myelin-synthesizing oligodendrocytes and is crucial to myelination in the developing nervous system. The gene encoding human KIR4.1 maps to chromosome 1. KIR4.2, also known as Kir1.3, is expressed in kidney, lung, heart, thymus and thyroid during development. The gene encoding human KIR4.2 maps to chromosome 21 in the Down syndrome chromosome region 1, and KIR4.2 may play a role in the pathogenesis of Downs syndrome. KIR5.1 forms functional channels only by coexpression with either KIR4.1 or KIR4.2 in the kidney and pancreas. The gene encoding human KIR5.1 maps to chromosome 17.
Synonyms: ATP dependent inwardly rectying potassium channel Kir4.1, ATP sensitive inward rectier potassium channel 10, ATP-dependent inwardly rectying potassium channel Kir4.1, ATP-sensitive inward rectier potassium channel 10, BIRK10, Glial ATP dependent inwardly rectying potassium channel KIR4.1, Inward rectier K+ channel Kir1.2, Inward rectier K+ channel KIR1.2, Inwardly rectying potassium channel Kir1.2, inwardly rectying subfamily J member 10, KCNJ 10, Kcnj10, KCNJ13 PEN, KIR1.2, KIR4.1, Potassium channel, Potassium channel inwardly rectying subfamily J member 10, Potassium inwardly rectying channel subfamily J member 10, SESAME, IRK10_HUMAN.
Subcellular locations: Extracellular

Gene ID: 3766

Pathways: Dicarboxylic Acid Transport, Regulation of long-term Neuronal Synaptic Plasticity