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FEN1 antibody (AbBy Fluor® 488)

This Rabbit Polyclonal antibody specifically detects FEN1 in WB and IF (p). It exhibits reactivity toward Human, Mouse and Rat.
Catalog No. ABIN1405180

Quick Overview for FEN1 antibody (AbBy Fluor® 488) (ABIN1405180)

Target

See all FEN1 Antibodies
FEN1 (Flap Structure-Specific Endonuclease 1 (FEN1))

Reactivity

  • 67
  • 45
  • 39
  • 5
  • 5
  • 5
  • 4
  • 4
  • 4
  • 4
  • 3
  • 3
  • 3
  • 1
  • 1
Human, Mouse, Rat

Host

  • 61
  • 11
Rabbit

Clonality

  • 56
  • 16
Polyclonal

Conjugate

  • 49
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
This FEN1 antibody is conjugated to AbBy Fluor® 488

Application

  • 60
  • 22
  • 22
  • 15
  • 12
  • 11
  • 9
  • 8
  • 4
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
  • Cross-Reactivity

    Human, Mouse, Rat

    Purification

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human FEN1

    Isotype

    IgG
  • Application Notes

    IF(IHC-P) 1:50-200

    Restrictions

    For Research Use only
  • Format

    Liquid

    Concentration

    1 μg/μL

    Buffer

    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

    Preservative

    ProClin

    Precaution of Use

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Storage

    -20 °C

    Storage Comment

    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

    Expiry Date

    12 months
  • Target

    FEN1 (Flap Structure-Specific Endonuclease 1 (FEN1))

    Alternative Name

    FEN1

    Background

    Synonyms: DNase IV, FEN-1, FEN1, FEN1_HUMAN, Flap endonuclease 1, Flap structure specic endonuclease 1, Flap structure-specic endonuclease 1, hFEN-1, hFEN1,Maturation factor 1, MF1, Rad2.

    Background: Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.

    Gene ID

    2237

    Pathways

    Telomere Maintenance, DNA Damage Repair, DNA Replication, Synthesis of DNA
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