MCPH1 antibody (AA 11-110) (Cy3)

Catalog No. ABIN1407915

This anti-MCPH1 antibody is a Rabbit Polyclonal antibody detecting MCPH1 in WB, IF (cc), IF (p). Suitable for Mouse.

Quick Overview for MCPH1 antibody (AA 11-110) (Cy3) (ABIN1407915)

Target: MCPH1 (Microcephalin 1 (MCPH1))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCPH1 antibody is conjugated to Cy3

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-MCPH1 Antibody (Cy3)

Binding Specificity: AA 11-110

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Dog

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Microcephalin 1/BRIT1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for MCPH1

Target: MCPH1 (Microcephalin 1 (MCPH1))

Alternative Name: Microcephalin 1/BRIT1

Background:

Synonyms: BRCT repeat inhibitor of TERT expression 1, BRIT 1, FLJ12847, Hypothetical protein FLJ12847, MCPH 1, MCPH1, MCPH1_HUMAN, MCT antibody Microcephalin 1, Microcephalin-1, Microcephaly primary autosomal recessive 1.

Background: Microcephalin modulates brain size and has been proliferating under strong positive selection for several thousand years, although the nature of the positive selection is poorly understood. Human Microcephalin contains three BRCA1 C-terminal (BRCT) domains and shares 57 % identity with its mouse ortholog, the most conserved regions being BRCT domains where there is 80 % identity. Predominant expression of human Microcephalin is observed in fetal brain, liver and kidney tissues and is expressed during neurogenesis in mice. Microcephalin displays significantly higher rates of protein evolution in primates than in rodents, this trend is most noticeable for the subset of genes associated with nervous system development. Microcephalin has a very young, single nucleotide, polymorphism haplotype associated with modern humans, this gene is presumably still evolving in Homo sapiens. It functions in DNA damage response and regulation of cell cycle checkpoints.

Pathways: Stem Cell Maintenance