MCPH1 antibody (AA 60-140)

Catalog No. ABIN7225086

The Rabbit Polyclonal anti-MCPH1 antibody is suitable to detect MCPH1 in samples from Human and Mouse. It has been validated for WB, ELISA, IHC and IF.

Quick Overview for MCPH1 antibody (AA 60-140) (ABIN7225086)

Target: MCPH1 (Microcephalin 1 (MCPH1))

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This MCPH1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)

Product Details anti-MCPH1 Antibody

Binding Specificity: AA 60-140

Purpose: Rabbit Anti-Microcephalin Polyclonal Antibody

Specificity: Microcephalin Polyclonal Antibody detects endogenous levels of Microcephalin protein.

Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from the N-terminal region of human Microcephalin at AA range: 60-140

Isotype: IgG

Application Details

Application Notes: Optimal working dilutions should be determined experimentally by the investigator. Suggested starting dilutions are as follows: WB 1:500-1:2000,IHC 1:100-1:300,ELISA 1:40000,IF 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Stable for one year at -20°C from date of shipment. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquot to avoid repeated freezing and thawing.

Expiry Date: 12 months

Target Details for MCPH1

Target: MCPH1 (Microcephalin 1 (MCPH1))

Alternative Name: Microcephalin

Background: MCPH1, MicrocephalinMCPH1 (microcephalin 1) encodes a DNA damage response protein. The encoded protein may play a role in G2/M checkpoint arrest via maintenance of inhibitory phosphorylation of cyclin-dependent kinase 1. Mutations in MCPH1 have been associated with primary autosomal recessive microcephaly 1 and premature chromosome condensation syndrome. Alternatively spliced transcript variants have been described.

Molecular Weight: 93kD

Gene ID: 79648

UniProt: Q8NEM0

Pathways: Stem Cell Maintenance