HS1BP3 antibody (AA 51-130) (HRP)

Catalog No. ABIN1409936

The Rabbit Polyclonal anti-HS1BP3 antibody has been validated for ELISA, IHC (p) and IHC (fro). It is suitable to detect HS1BP3 in samples from Human.

Quick Overview for HS1BP3 antibody (AA 51-130) (HRP) (ABIN1409936)

Target: HS1BP3 (HCLS1 Binding Protein 3 (HS1BP3))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This HS1BP3 antibody is conjugated to HRP

Application: ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Product Details anti-HS1BP3 Antibody (HRP)

Binding Specificity: AA 51-130

Cross-Reactivity: Human

Predicted Reactivity: Mouse,Rat,Dog,Cow,Sheep,Pig,Horse,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human HS1BP3

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for HS1BP3

Target: HS1BP3 (HCLS1 Binding Protein 3 (HS1BP3))

Alternative Name: HS1BP3

Background:

Synonyms: ETM2, FLJ14249, H1BP3_HUMAN, HCLS1 binding protein 3, HCLS1-binding protein 3, HS1 binding protein 3, HS1 BP3, HS1-BP3, HS1-binding protein 3, Hs1bp3, HSP1BP-3.

Background: HS1BP3 is a 392 amino acid protein that contains one PX (phox homology) domain, a leucine zipper, immunoreceptor tyrosine-based inhibitory motif-like motifs and multiple proline-rich regions. Expressed primarily in brain, HS1BP3 is encoded by a gene mapping to human chromosome 2p24.1. The gene encoding HS1BP3 is frequently mutated in familial essential tremor, a disorder characterized by kinetic tremor the the hands, voice or head, though there is no correlation to Parkinson disease. HS1BP3 interacts with HAX-1?s SH3 domain, and may also play a role in the regulation of catecholamine and serotonin metabolism. Acting as a regulator of IL-2 signaling, HS1BP3 is likely involved in lymphocyte activation.