CTRP5 antibody (AA 191-243) (Cy5.5)

Catalog No. ABIN1410815

The Rabbit Polyclonal anti-CTRP5 antibody is suitable to detect CTRP5 in samples from Mouse. It has been validated for WB, IF (cc) and IF (p).

Quick Overview for CTRP5 antibody (AA 191-243) (Cy5.5) (ABIN1410815)

Target: CTRP5 (C1QTNF5) (C1q and Tumor Necrosis Factor Related Protein 5 (C1QTNF5))

Reactivity: Mouse

Host: Rabbit

Clonality: Polyclonal

Conjugate: This CTRP5 antibody is conjugated to Cy5.5

Application: Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details anti-CTRP5 Antibody (Cy5.5)

Binding Specificity: AA 191-243

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Pig,Rabbit

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CTRP5

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for CTRP5

Target: CTRP5 (C1QTNF5) (C1q and Tumor Necrosis Factor Related Protein 5 (C1QTNF5))

Alternative Name: CTRP5

Background:

Synonyms: C1q and tumor necrosis factor related protein 5, C1QTNF5, Complement C1q tumor necrosis factor related protein 5 precursor, LORD, C1QT5_HUMAN.

Background: Members of the C1q superfamily have diverse functions that are related to cell adhesion and basement membrane components. CTRP5 (Complement C1q tumor necrosis factor-related protein 5) is a 243 amino acid secreted and membrane-associated protein that contains a collagen-like domain and a C1q domain. CTRP5 is a short-chain collagen that is expressed in retinal pigment epithelium as well as brain, lung, liver and placenta. By forming an extracellular hexagonal lattice, CTRP5 facilitates the adhesion of basal retinal pigment epithelium to Bruch?s membrane, the innermost layer of the choroid. A mutation within the C1q domain of CTRP5 results in abnormal high molecular weight aggregate formation, which alters its structure and interactions. This mutation may result in the presentation of late-onset retinal degeneration (LORD), an autosomal dominant disorder that is characterized by punctate yellow-white deposits in the retinal fundus and night blindness.

Gene ID: 114902

UniProt: Q9BXJ0