GDAP1 antibody (AA 151-230) (HRP)

Catalog No. ABIN1410854

The Rabbit Polyclonal anti-GDAP1 antibody is suitable to detect GDAP1 in samples from Human. It has been validated for WB, IHC (fro) and IHC (p).

Quick Overview for GDAP1 antibody (AA 151-230) (HRP) (ABIN1410854)

Target: GDAP1 (Ganglioside-Induced Differentiation-Associated Protein 1 (GDAP1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This GDAP1 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-GDAP1 Antibody (HRP)

Binding Specificity: AA 151-230

Purpose: GDAP1 Polyclonal Antibody, HRP Conjugated

Cross-Reactivity: Mouse

Predicted Reactivity: Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit,Orangutan

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human GDAP1

Isotype: IgG

Application Details

Application Notes: WB(1:300-5000),

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for GDAP1

Target: GDAP1 (Ganglioside-Induced Differentiation-Associated Protein 1 (GDAP1))

Alternative Name: GDAP1

Background:

Synonyms: Ganglioside induced dferentiation associated protein 1, Ganglioside-induced dferentiation-associated protein 1, GDAP1, GDAP1_HUMAN.

Background: Glutathione S-transferases (GSTs) function to conjugate reduced glutathione to many exogenous and endogenous hydrophobic electrophiles. Although it shares the carboxy and amino-terminal glutathione S-transferase domains, GDAP1 is characterized as a GST-like protein because it contains an extended GST domain II and a predicted transmembrane domain, two characteristics which are unusual for GST family members. GDAP1 may function in a signal transduction pathway that is responsible for ganglioside-induced neurite differentiation and also may play a role in protecting myelin membranes from free-radical damage. Mutations in the gene encoding GDAP1 is the cause of many forms of Charcot-Marie-Tooth disease, a common inherited disorder of the peripheral nervous system that is characterized by reduced nerve conduction velocities, slow progressive distal muscle atrophy and absent deep tendon reflexes.