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GARP antibody (AA 856-960) (Cy3)

CNGB1 Reactivity: Human IF (p), IF (cc) Host: Rabbit Polyclonal Cy3
Catalog No. ABIN1413009
  • Target See all GARP (CNGB1) Antibodies
    GARP (CNGB1) (Cyclic Nucleotide Gated Channel beta 1 (CNGB1))
    Binding Specificity
    • 14
    • 4
    • 3
    • 1
    • 1
    • 1
    AA 856-960
    Reactivity
    • 30
    • 12
    • 12
    • 1
    • 1
    Human
    Host
    • 30
    Rabbit
    Clonality
    • 30
    Polyclonal
    Conjugate
    • 7
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    This GARP antibody is conjugated to Cy3
    Application
    • 12
    • 12
    • 10
    • 6
    • 3
    • 3
    • 2
    • 2
    • 1
    Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
    Predicted Reactivity
    Human,Mouse,Rat,Cow,Sheep,Pig,Horse,Rabbit
    Purification
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human CNGB1
    Isotype
    IgG
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    Discover our top product CNGB1 Primary Antibody
  • Application Notes
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Storage
    -20 °C
    Storage Comment
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Expiry Date
    12 months
  • Target
    GARP (CNGB1) (Cyclic Nucleotide Gated Channel beta 1 (CNGB1))
    Alternative Name
    CNG4/GARP (CNGB1 Products)
    Synonyms
    CNCG2 antibody, CNCG3L antibody, CNCG4 antibody, CNG4 antibody, CNGB1B antibody, GAR1 antibody, GARP antibody, RCNC2 antibody, RCNCb antibody, RCNCbeta antibody, RP45 antibody, Gm1959 antibody, Cngb1b antibody, CNGB1 antibody, si:ch211-160j6.1 antibody, cyclic nucleotide gated channel beta 1 antibody, cyclic nucleotide gated channel beta 1a antibody, CNGB1 antibody, Cngb1 antibody, cngb1a antibody
    Background

    Synonyms: CNCG2, CNCG3L, CNCG4, CNG 4, CNG-4, CNG channel 4, CNG channel beta 1, CNG4, CNGB 1, CNGB1, CNGB1B, Cyclic nucleotide gated cation channel 4, Cyclic nucleotide gated cation channel, Cyclic nucleotide gated cation channel beta 1, Cyclic nucleotide gated cation channel gamma, Cyclic nucleotide gated cation channel modulatory subunit, Cyclic nucleotide gated channel photoreceptor cGMP gated 3 gamma like, Cyclic nucleotide gated channel beta 1, GAR1, Glutamic acid rich protein, RCNC2, RCNCb, RCNCbeta, RP45, CNGB1_HUMAN.

    Background: Cyclic nucleotide-gated (CNG) cation channels are heteromeric complexes made up of principal alpha and modulatory beta subunits (1,2). The alpha subunits consist of CNG1-3 and form functional cation channels by themselves (1,2). The beta subunits consist of CNG4-6 and, unlike the alpha subunits, do not form functional channels, but rather modify the properties of channels (1,2). CNG channels are essential components of olfactory and visual transduction (1,2). In olfactory neurons, CNG2, CNG4.3 and CNG5 form Ca2+ permeable channels, which open and depolarize the cell in response to cAMP (1-3). In rod photoreceptors, CNG1 and CNG4.1 combine to form Ca ion permeable channels, which give rise to a current in response to cGMP (1-3). CNG3 and CNG6 are expressed in cone receptors and may combine to form a native cGMP-activated channel (2,3). CNG channels have been implicated in other areas (4-6). CNG1 is also expressed in medium-sized and small-sized arteries, suggesting a role for CNG in the regulation of arterial blood pressure and of blood supply to different regions (4). CNG1, CNG4.1 and CNG4.2 have been detected in the rat pineal gland (5). CNG2, CNG4.3 and CNG5 are present in GT1 cell lines and may play a role in the secretion of gonadotropin-releasing hormone (6).

    UniProt
    Q14028
    Pathways
    Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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