DLGAP2 antibody (AA 251-360) (HRP)

Catalog No. ABIN1413284

Product Details anti-DLGAP2 Antibody (HRP)

Target: DLGAP2 (Discs, Large (Drosophila) Homolog-Associated Protein 2 (DLGAP2))

Binding Specificity: AA 251-360

Reactivity: Human, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This DLGAP2 antibody is conjugated to HRP

Application: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Cross-Reactivity: Human, Rat

Predicted Reactivity: Mouse

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SAPAP2/DLGAP2

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for DLGAP2

Target: DLGAP2 (Discs, Large (Drosophila) Homolog-Associated Protein 2 (DLGAP2))

Alternative Name: SAPAP2/DLGAP2 (DLGAP2 Products)

Synonyms: PSD-95 antibody, DAP2 antibody, SAPAP2 antibody, 6430596N04Rik antibody, Sapap2 antibody, DLG associated protein 2 antibody, disks large-associated protein 2 antibody, discs, large (Drosophila) homolog-associated protein 2a antibody, discs, large (Drosophila) homolog-associated protein 2 antibody, DLGAP2 antibody, LOC463960 antibody, dlgap2a antibody, LOC100447448 antibody, Dlgap2 antibody

Background:

Synonyms: DAP-2, DAP2, Discs large Drosophila homolog associated protein 2, Discs large homolog associated protein 2, Disks large-associated protein 2, Dlgap2, DLGP2_HUMAN, PSD-95/SAP90-binding protein 2, SAP90/PSD-95-associated protein 2, SAPAP2, hide.

Background: A guanylate kinase is a phosphotransferase that produces ADP and GDP from the substrates ATP and GMP. SAPAP2, also known as DAP-2 (Disks large-associated protein 2) and PSD-95/SAP90-binding protein 2, is a 1054 amino acid protein that localizes to the postsynaptic membrane of neuronal cells of the brain and kidney. SAPAP2 likely acts as a signaling molecule which interacts with the human genes DLG1 and DLG4/PSD-95. The gene encoding SAPAP2, DLGAP2, maps to human chromosome 8. Consisting of nearly 146 million base pairs, chromosome 8 encodes over 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that maps to chromosome 8.