SARM1 antibody (AA 340-380) (HRP)

Catalog No. ABIN1418134

This Rabbit Polyclonal antibody specifically detects SARM1 in WB and IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for SARM1 antibody (AA 340-380) (HRP) (ABIN1418134)

Target: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This SARM1 antibody is conjugated to HRP

Application: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-SARM1 Antibody (HRP)

Binding Specificity: AA 340-380

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human SARM1

Isotype: IgG

Application Details

Application Notes: WB 1:300-5000
IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for SARM1

Target: SARM1 (Sterile alpha and TIR Motif Containing 1 (SARM1))

Alternative Name: SARM1

Background:

Synonyms: SARM, SAMD2, MyD88-5, Sterile alpha and TIR motif-containing protein 1, Sterile alpha and Armadillo repeat protein, Sterile alpha motif domain-containing protein 2, SAM domain-containing protein 2, Tir-1 homolog, SARM1, KIAA0524

Background: Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury. Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site. Can activate neuronal death in response to stress. Regulates dendritic arborization through the MAPK4-JNK pathway. Involved in innate immune response. Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38.

Gene ID: 23098

UniProt: Q6SZW1

Pathways: TLR Signaling, Activation of Innate immune Response, Toll-Like Receptors Cascades