Eukaryotic Translation Initiation Factor 3, Subunit M (EIF3M) antibody (Cy3)

Catalog No. ABIN1418321

The Rabbit Polyclonal anti-Eukaryotic Translation Initiation Factor 3, Subunit M antibody is suitable to detect Eukaryotic Translation Initiation Factor 3, Subunit M in samples from Human, Mouse and Rat. It has been validated for WB and IF (p).

Quick Overview for Eukaryotic Translation Initiation Factor 3, Subunit M (EIF3M) antibody (Cy3) (ABIN1418321)

Target: Eukaryotic Translation Initiation Factor 3, Subunit M (EIF3M)

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: Cy3

Application: Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Product Details

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human PCID1

Isotype: IgG

Application Details

Application Notes: IF(IHC-P) 1:50-200

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details

Target: Eukaryotic Translation Initiation Factor 3, Subunit M (EIF3M)

Alternative Name: PCID1

Background:

Synonyms: B5 receptor, Dendritic cell protein, e3m, E3M_HUMAN, Eukaryotic translation initiation factor 3 subunit M, Fetal lung protein B5, FLJ29030, GA17, hfl B5, hFL-B5, PCI domain containing 1 herpesvirus entry mediator, PCI domain-containing protein 1, PCID1.

Background: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. May favor virus entry in case of infection with herpes simplex virus 1 (HSV1) or herpes simplex virus 2 (HSV2).

Gene ID: 10480

Pathways: Ribonucleoprotein Complex Subunit Organization