ZNRF3 antibody (AA 120-165) (HRP)

Catalog No. ABIN1418944

This Rabbit Polyclonal antibody specifically detects ZNRF3 in IHC (p). It exhibits reactivity toward Human, Mouse and Rat.

Quick Overview for ZNRF3 antibody (AA 120-165) (HRP) (ABIN1418944)

Target: ZNRF3 (Zinc and Ring Finger Protein 3 (ZNRF3))

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This ZNRF3 antibody is conjugated to HRP

Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Product Details anti-ZNRF3 Antibody (HRP)

Binding Specificity: AA 120-165

Cross-Reactivity: Human, Mouse, Rat

Purification: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human ZNRF3

Isotype: IgG

Application Details

Application Notes: IHC-P 1:200-400

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.

Storage: -20 °C

Storage Comment: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Expiry Date: 12 months

Target Details for ZNRF3

Target: ZNRF3 (Zinc and Ring Finger Protein 3 (ZNRF3))

Alternative Name: ZNRF3

Background:

Synonyms: RNF203, BK747E2.3, E3 ubiquitin-protein ligase ZNRF3, RING finger protein 203, Zinc/RING finger protein 3, ZNRF3, KIAA1133

Background: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone.

Gene ID: 84133

UniProt: Q9ULT6

Pathways: WNT Signaling